SOX2 binds the MITF promoter

Stable Identifier
R-HSA-9732125
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SOX2 binds the MITF promoter
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SOX2 is a transcriptional repressor that is present on the promoter of the MITF gene in neural crest cells prior to melanocyte fate specification. With FOXD3, SOX2 represses MITF expression and promotes instead the development of the Schwann cell precursor fate (Adameyko et al, 2012). Although the mechanisms for lifting SOX2-mediated repression in the melanocyte cell line are not known, once expressed, MITF itself represses further SOX2 expression (Adameyko et al, 2012; reviewed in Mort et al, 2015; Goding and Arnheiter, 2019).
Literature References
PubMed ID Title Journal Year
31123060 MITF-the first 25 years

Arnheiter, H, Goding, CR

Genes Dev 2019
22186729 Sox2 and Mitf cross-regulatory interactions consolidate progenitor and melanocyte lineages in the cranial neural crest

Favaro, R, Ernfors, P, Kitambi, SS, Lallemend, F, Zaitoun, I, Suter, U, Furlan, A, Birchmeier, C, Nicolis, S, Müller, T, Blanchart, A, Takahashi, Y, Zinin, N, Aranda, S, Lübke, M, Adameyko, I

Development 2012
25670789 The melanocyte lineage in development and disease

Jackson, IJ, Patton, EE, Mort, RL

Development 2015
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Authored
Rothfels, K  (2023-01-26)
Reviewed
de la Serna, IL  (2024-05-21)
Arnheiter, H  (2024-02-26)
Created
Rothfels, K  (2021-05-26)
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