Reactome | KPNA6 [nucleoplasm]

KPNA6 [nucleoplasm]

Stable Identifier

R-HSA-9734665

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Importin subunit alpha-7, IMA7_HUMAN

Locations in the PathwayBrowser

Expand all

DNA Replication (Homo sapiens)

- DNA Replication Pre-Initiation (Homo sapiens)
  - Assembly of the pre-replicative complex (Homo sapiens)
    - Assembly of the ORC complex at the origin of replication (Homo sapiens)
      - ORC6 translocates to the nucleus (Homo sapiens)
        
        KPNA1,KPNA6:KPNB1 [nucleoplasm] (Homo sapiens)
        
        KPNA1,KPNA6 [nucleoplasm] (Homo sapiens)
        
        KPNA6 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:O60684 KPNA6

Gene Names

KPNA6, IPOA7

Chain

chain:1-536

Reference Genes

BioGPS Gene:23633 KPNA6

COSMIC (genes):KPNA6 KPNA6

CTD Gene:23633 KPNA6

dbSNP Gene:23633 KPNA6

ENSEMBL:ENSG00000025800 KPNA6

HGNC:6399 KPNA6

KEGG:hsa:23633 KPNA6

Monarch:23633 KPNA6

NCBI Gene:23633 KPNA6

OMIM:610563 KPNA6

UCSC:O60684 KPNA6

Reference Transcript

RefSeq:NM_012316.4 KPNA6

Other Identifiers

11723267_a_at

11723268_at

11723269_at

11723270_x_at

11723271_x_at

16661956

212101_PM_at

212101_at

212102_PM_s_at

212102_s_at

212103_3p_at

212103_PM_at

212103_at

226976_PM_at

226976_at

2328675

2328683

2328685

2328686

2328687

2328688

2328689

2328690

2328692

2328693

2328694

2328696

2328697

2328698

2328699

2328700

2328701

2328702

2328703

2328704

2328705

2328706

2328707

2328714

2328715

2328716

2328717

2328718

2328719

2328720

23633

35443_at

40275_at

43029_at

44151_at

7899688

A_24_P128563

A_33_P3214874

GE62857

GE81786

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006366

GO:0006606

GO:0006607

GO:0006886

GO:0006913

GO:0008139

GO:0015031

GO:0016020

GO:0019079

GO:0022414

GO:0030682

GO:0042564

GO:0043226

GO:0043657

GO:0045944

GO:0060135

GO:0061608

GO:0075506

GO:0140104

GO:1900017

GO:1903902

HMNXSV003032512

HMNXSV003050048

Hs.301553.0.S1_3p_at

Hs.301553.1.S2_3p_a_at

Hs.301553.1.S3_3p_at

ILMN_1696021

PH_hs_0024219

TC01000419.hg

TC01004298.hg

Participates

as a member of

KPNA1,KPNA6 [nucleoplasm] (Homo sapiens)

Other forms of this molecule

KPNA6 [cytosol]

Inferred To

KPNA6 [nucleoplasm] (Bos taurus)

KPNA6 [nucleoplasm] (Canis familiaris)

KPNA6 [nucleoplasm] (Gallus gallus)

KPNA6 [nucleoplasm] (Sus scrofa)

kpna6 [nucleoplasm] (Xenopus tropicalis)

Kap-alpha1 [nucleoplasm] (Drosophila melanogaster)

Kpna6 [nucleoplasm] (Mus musculus)

Kpna6 [nucleoplasm] (Rattus norvegicus)

cut15 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_036448.1

ENSEMBL

ENST00000373625, ENSP00000362728

OpenTargets

ENSG00000025800

HPA

ENSG00000025800-KPNA6

PRO

O60684

Pharos - Targets

O60684

GlyGen

O60684

HMDB Protein

HMDBP08461

PDB

4UAD, 7RHT

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43148 RNMT	1	RNMT [nucleoplasm] (R-HSA-77060)	0.742	6
UniProt:Q14974 KPNB1	5	KPNB1 [cytosol] (R-HSA-180733) KPNB1 [nucleoplasm] (R-HSA-180714) KPNB1 [specific granule lumen] (R-HSA-6799646) KPNB1 [extracellular region] (R-HSA-6806306) KPNB1 [ficolin-1-rich granule lumen] (R-HSA-6800978)	0.688	4
UniProt:P20700 LMNB1	8	LMNB1 [nucleoplasm] (R-HSA-264867) LMNB1(1-231) [nuclear envelope] (R-HSA-352244) LMNB1(232-586) [nuclear envelope] (R-HSA-352248) LMNB1 [cytosol] (R-HSA-2995384) p-S395, S405-LMNB1 [nucleoplasm] (R-HSA-5228738) p-S23, S395, S405-LMNB1 [nucleoplasm] (R-HSA-5229018) LMNB1(2-586) [nuclear envelope] (R-HSA-912402) p-S23,S393-LMNB1 [nucleoplasm] (R-HSA-8868341)	0.666	4
UniProt:P02545 LMNA	3	LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-646) [nuclear envelope] (R-HSA-535479)	0.569	5
UniProt:P01583 IL1A	4	Myr82K-Myr83K-IL1A [extracellular region] (R-HSA-445746) IL1A(1-112) [cytosol] (R-HSA-449059) 2xMyri-IL1A [cytosol] (R-HSA-449054) IL1A(1-271) [cytosol] (R-HSA-449042)	0.556	3
UniProt:P46087 NOP2	1	NOP2 [nucleoplasm] (R-HSA-6790922)	0.556	3
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.556	3
UniProt:Q96C86 DCPS	1	DCPS [cytosol] (R-HSA-429988)	0.556	5
UniProt:Q9Y5V3 MAGED1	1	MAGED1 [cytosol] (R-HSA-196002)	0.556	3
UniProt:P39687 ANP32A	1	ANP32A [nucleoplasm] (R-HSA-450467)	0.547	2
UniProt:P03466 NP	6	NP [Golgi membrane] (R-FLU-195740) NP [plasma membrane] (R-FLU-195752) NP [extracellular region] (R-FLU-169251) NP [endosome lumen] (R-FLU-189141) NP [cytosol] (R-FLU-188848) NP [nucleoplasm] (R-FLU-188832)	0.547	5
UniProt:P52294 KPNA1	2	KPNA1 [cytosol] (R-HSA-180612) KPNA1 [nucleoplasm] (R-HSA-188865)	0.527	2
UniProt:Q13547 HDAC1	2	HDAC1 [nucleoplasm] (R-HSA-205021) monoSUMO1-K444,K476-HDAC1 [nucleoplasm] (R-HSA-4616030)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	2
UniProt:P52298 NCBP2	2	NCBP2 [cytosol] (R-HSA-162458) NCBP2 [nucleoplasm] (R-HSA-51463)	0.527	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.527	2
UniProt:Q14653 IRF3	6	IRF3 [cytosol] (R-HSA-166251) IRF3(2-271) [cytosol] (R-HSA-9729696) IRF3(272-427) [cytosol] (R-HSA-9729737) p-4S,T404-IRF3 [cytosol] (R-HSA-166258) p-4S,T404-IRF3 [nucleoplasm] (R-HSA-177654) p-5S,T404-IRF3 [nucleoplasm] (R-HSA-936418)	0.524	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	8

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