ORC6 translocates to the nucleus

Stable Identifier
R-HSA-9734713
Type
Reaction [BlackBoxEvent]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
ORC6 translocates to the nucleus
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Phosphorylation at threonine residue T195 facilitates translocation of ORC6 to the nucleus (Ghosh et al. 2011). In the nucleus, ORC6 is thought to dissociate from the importin complex.

Literature References
PubMed ID Title Journal Year
21555516 Assembly of the human origin recognition complex occurs through independent nuclear localization of its components

Ghosh, S, Zhao, Y, Vassilev, AP, Zhang, J, DePamphilis, ML

J Biol Chem 2011
Participants
Input
Output
Participates
as an event of
Orthologous Events
ORC6 translocates to the nucleus (Canis familiaris)
ORC6 translocates to the nucleus (Danio rerio)
ORC6 translocates to the nucleus (Drosophila melanogaster)
ORC6 translocates to the nucleus (Gallus gallus)
ORC6 translocates to the nucleus (Mus musculus)
ORC6 translocates to the nucleus (Rattus norvegicus)
ORC6 translocates to the nucleus (Schizosaccharomyces pombe)
ORC6 translocates to the nucleus (Sus scrofa)
Authored
Kusic-Tisma, J  (2021-06-18)
Created
Orlic-Milacic, M  (2021-06-18)
Cite Us!