ORC1 translocates to the nucleus

Stable Identifier
R-HSA-9734730
Type
Reaction [omitted]
Species
Homo sapiens
Compartment
cytosol, nucleoplasm
ReviewStatus
5/5
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ORC1 translocates to the nucleus
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ORC1 translocates to the nucleus independently of other ORC subunits. No association between ORC1 and importin alpha (KPNA) proteins has been detected. A single nuclear localization signal (NLS) is required for the nuclear retention of ORC1 (Ghosh et al. 2011).
Literature References
PubMed ID Title Journal Year
21555516 Assembly of the human origin recognition complex occurs through independent nuclear localization of its components

Ghosh, S, Zhao, Y, Vassilev, AP, Zhang, J, DePamphilis, ML

J Biol Chem 2011
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Authored
Kusic-Tisma, J  (2021-06-18)
Created
Orlic-Milacic, M  (2021-06-18)
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