Reactome | YBX1 [cytosol]

YBX1 [cytosol]

Stable Identifier

R-HSA-9736840

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

YB-1, Y box transcription factor, Nuclease sensitive element binding protein 1, Y box binding protein-1, Y-box transcription factor, CCAAT-binding transcription factor I subunit A, CBF-A, Enhancer factor I subunit A, EFI-A, DNA-binding protein B, DBPB

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P67809 YBX1

Gene Names

YBX1, NSEP1, YB1

Chain

initiator methionine:, chain:2-324

Reference Genes

BioGPS Gene:4904 YBX1

COSMIC (genes):YBX1 YBX1

CTD Gene:4904 YBX1

dbSNP Gene:4904 YBX1

ENSEMBL:ENSG00000065978 YBX1

HGNC:8014 YBX1

KEGG:hsa:4904 YBX1

Monarch:4904 YBX1

NCBI Gene:4904 YBX1

OMIM:154030 YBX1

UCSC:P67809 YBX1

Reference Transcript

RefSeq:NM_004559.4 YBX1

Other Identifiers

11756972_x_at

16663317

208627_PM_s_at

208627_s_at

208628_PM_s_at

208628_s_at

2332635

2332667

2332668

2332669

2332670

2332671

2332672

2332673

2332674

2332675

2332676

2332677

2332678

2332679

2332680

2332689

2332691

2332692

2332694

2332695

2332697

2332698

3066582

3066583

3066590

3205034

3205037

3205038

3205039

3205040

3205042

32340_s_at

3568965

3568967

3568969

4904

7900585

A_14_P117144

A_23_P34767

GE57491

GO:0000122

GO:0000932

GO:0001701

GO:0003676

GO:0003677

GO:0003682

GO:0003690

GO:0003697

GO:0003723

GO:0003729

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005689

GO:0005737

GO:0005783

GO:0005829

GO:0005886

GO:0006355

GO:0006397

GO:0008380

GO:0008544

GO:0010468

GO:0010494

GO:0016071

GO:0017148

GO:0035198

GO:0043226

GO:0043231

GO:0045202

GO:0045944

GO:0048255

GO:0048598

GO:0048856

GO:0050658

GO:0051020

GO:0051031

GO:0051154

GO:0051781

GO:0060090

GO:0062153

GO:0070062

GO:0070934

GO:0070937

GO:0071204

GO:0098761

GO:1900152

GO:1903608

GO:1990428

GO:1990837

GO:1990904

GO:2000767

GO:2000773

HMNXSV003006738

Hs.74497.1.S1_3p_a_at

Hs.74497.2.S1_3p_a_at

Hs.74497.2.S1_3p_x_at

ILMN_1669424

ILMN_2124769

J03827_at

PH_hs_0028962

TC01000531.hg

Participates

as an input of

JAK2-activated MAPKs phosphorylate YBX1 (Homo sapiens)

Other forms of this molecule

p-S32,S36-YBX1 [nucleoplasm]

p-S32,S36-YBX1 [cytosol]

YBX1 [nucleoplasm]

YBX1 [extracellular region]

Inferred To

Ybx1 [cytosol] (Mus musculus)

Ybx1 [cytosol] (Rattus norvegicus)

cey-1 [cytosol] (Caenorhabditis elegans)

cey-4 [cytosol] (Caenorhabditis elegans)

cey-3 [cytosol] (Caenorhabditis elegans)

LOC479011 [cytosol] (Canis familiaris)

yps [cytosol] (Drosophila melanogaster)

cey-2 [cytosol] (Caenorhabditis elegans)

YBX1 [cytosol] (Bos taurus)

YBX1 [cytosol] (Canis familiaris)

YBX1 [cytosol] (Gallus gallus)

YBX1 [cytosol] (Sus scrofa)

Homologues of YBX1 [cytosol] (Caenorhabditis elegans)

Homologues of YBX1 [cytosol] (Canis familiaris)

ybx1 [cytosol] (Danio rerio)

ybx1 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_004550.2

OpenTargets

ENSG00000065978

ENSEMBL

ENSP00000361626, ENST00000321358

HPA

ENSG00000065978-YBX1

PRO

P67809

Pharos - Targets

P67809

GlyGen

P67809

PDB

6A6L, 5YTS, 5YTX, 5YTT, 6LMR, 6KTC, 6LMS, 6KUG, 5YTV, 1H95

Interactors (124)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q07021 C1QBP	3	C1QBP [plasma membrane] (R-HSA-158123) C1QBP [mitochondrial matrix] (R-HSA-9645697) C1QBP [cytosol] (R-HSA-9645690)	0.918	13
UniProt:P26196 DDX6	1	DDX6 [cytosol] (R-HSA-430032)	0.816	12
UniProt:Q9NR30 DDX21	1	DDX21 [nucleoplasm] (R-HSA-5250652)	0.773	5
UniProt:P16989 YBOX3			0.773	5
UniProt:O43390 HNRNPR	1	HNRNPR [nucleoplasm] (R-HSA-71951)	0.773	5
UniProt:O60506 HNRPQ			0.773	5
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.767	11
UniProt:Q96EY7 PTCD3	1	PTCD3 [mitochondrial inner membrane] (R-HSA-5368165)	0.744	4
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.708	4
UniProt:Q4G0J3 LARP7			0.706	5
UniProt:Q6ZN17 LN28B			0.695	4
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.69	6
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.677	8
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.662	6
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001)	0.662	6
UniProt:P16403 H1-2	1	HIST1H1C [nucleoplasm] (R-HSA-211237)	0.643	4
UniProt:Q9BYC9 MRPL20	1	MRPL20 [mitochondrial inner membrane] (R-HSA-5368243)	0.643	3
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.643	4
UniProt:P51398 DAP3	1	DAP3 [mitochondrial inner membrane] (R-HSA-5368174)	0.643	3
UniProt:Q9BYD6 MRPL1	1	MRPL1 [mitochondrial inner membrane] (R-HSA-5368196)	0.643	3
UniProt:P82650 MRPS22	1	MRPS22 [mitochondrial inner membrane] (R-HSA-5368259)	0.643	3
UniProt:Q9P0M9 MRPL27	1	MRPL27 [mitochondrial inner membrane] (R-HSA-5368189)	0.643	3
UniProt:P09001 MRPL3	1	MRPL3 [mitochondrial inner membrane] (R-HSA-5368242)	0.643	3
UniProt:P49406 MRPL19	1	MRPL19 [mitochondrial inner membrane] (R-HSA-5368215)	0.643	3
UniProt:Q9Y6H1 CHCHD2	2	2xHC-CHCHD2 [mitochondrial intermembrane space] (R-HSA-6800100) CHCHD2 [mitochondrial intermembrane space] (R-HSA-1307777)	0.643	4
UniProt:Q7Z6M2 FBX33			0.641	6
UniProt:Q9Y6M1 IGF2BP2	1	IGF2BP2 [cytosol] (R-HSA-428302)	0.63	6
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	13
UniProt:O00571 DDX3X	3	DDX3X [secretory granule lumen] (R-HSA-6801275) DDX3X [extracellular region] (R-HSA-6806507) DDX3X [ficolin-1-rich granule lumen] (R-HSA-6801273)	0.613	6
UniProt:P19712-PRO_0000038050			0.599	4
UniProt:Q99IB8-PRO_0000045599			0.577	3
UniProt:P62310 LSM3	2	LSM3 [nucleoplasm] (R-HSA-6806807) LSM3 [cytosol] (R-HSA-429894)	0.573	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	11
UniProt:P13693 TCTP			0.567	4
UniProt:P37108 SRP14	4	SRP14 [cytosol] (R-HSA-264941) SRP14 [ficolin-1-rich granule lumen] (R-HSA-6800439) SRP14 [extracellular region] (R-HSA-6806495) SRP14 [secretory granule lumen] (R-HSA-6800938)	0.564	2
UniProt:Q7Z2W4 ZC3HAV1	2	ZC3HAV1(2-624)-BRAF(439-766) fusion [cytosol] (R-HSA-6802506) ZC3HAV1(2-624)-p-BRAF(439-766) fusion [cytosol] (R-HSA-6802557)	0.564	4
UniProt:Q96AG4 LRC59			0.564	2
UniProt:Q14694 USP10	3	USP10 [cytosol] (R-HSA-6782974) K63polyUb-USP10 [cytosol] (R-HSA-6782986) USP10 [nucleoplasm] (R-HSA-3222218)	0.564	2
UniProt:Q9NUL7 DDX28			0.564	2
UniProt:Q7L2E3 DHX30			0.564	2
UniProt:Q9Y2T7 YBOX2			0.564	2
UniProt:Q13616 CUL1	3	CUL1 [cytosol] (R-HSA-174230) CUL1 [nucleoplasm] (R-HSA-187551) G76-NEDD8-K720-CUL1 [cytosol] (R-HSA-8952519)	0.564	2
UniProt:O95363 FARS2	1	FARS2(1-?) [mitochondrial matrix] (R-HSA-379565)	0.564	2
IntAct:EBI-6857440 NS3			0.558	3
UniProt:Q86U42 PABPN1	2	PABPN1 [cytosol] (R-HSA-9822424) PABPN1 [nucleoplasm] (R-HSA-72008)	0.558	4
UniProt:O95613 PCNT	8	PCNT [cytosol] (R-HSA-380290) PolyUb-Misfolded PCNT [late endosome lumen] (R-HSA-9660016) PCNT [cilium] (R-HSA-9639683) Misfolded PCNT [cilium] (R-HSA-9639705) Misfolded PCNT [cytosol] (R-HSA-9640102) Ub-Misfolded PCNT [cytosol] (R-HSA-9641122) PolyUb-Misfolded PCNT [cytosol] (R-HSA-9641112) PolyUb-Misfolded PCNT [lysosomal lumen] (R-HSA-9660027)	0.556	4
UniProt:Q13148 TADBP			0.556	6
UniProt:Q9C0C9 UBE2O	1	UBE2O [cytosol] (R-HSA-947641)	0.547	2
UniProt:O76021 RL1D1			0.527	2
UniProt:P16401 H1-5	1	HIST1H1B [nucleoplasm] (R-HSA-211248)	0.527	2
UniProt:P82675 MRPS5	1	MRPS5 [mitochondrial inner membrane] (R-HSA-5368176)	0.527	2
UniProt:Q9HCE1 MOV10	1	MOV10 [cytosol] (R-HSA-427772)	0.527	2
UniProt:P14866 HNRNPL	1	HNRNPL [nucleoplasm] (R-HSA-71947)	0.527	3
UniProt:Q9Y2Q9 MRPS28	1	MRPS28 [mitochondrial inner membrane] (R-HSA-5368201)	0.527	2
UniProt:O95503 CBX6	1	CBX6 [nucleoplasm] (R-HSA-3229071)	0.527	2
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	4
UniProt:Q16540 MRPL23	1	MRPL23 [mitochondrial inner membrane] (R-HSA-5368179)	0.527	2
UniProt:Q15050 RRS1			0.527	2
UniProt:Q7Z2W9 MRPL21	1	MRPL21 [mitochondrial inner membrane] (R-HSA-5368231)	0.527	2
UniProt:Q9H361 PABP3			0.527	2
UniProt:Q5T653 MRPL2	1	MRPL2 [mitochondrial inner membrane] (R-HSA-5368170)	0.527	3
UniProt:Q14103-4 HNRNPD	2	HNRNPD-4 [cytosol] (R-HSA-450442) Ub-HNRNPD-4 [cytosol] (R-HSA-451232)	0.527	3
UniProt:P10412 H1-4	1	HIST1H1E [nucleoplasm] (R-HSA-211251)	0.527	3
UniProt:Q9H9J2 MRPL44	1	MRPL44 [mitochondrial inner membrane] (R-HSA-5368245)	0.527	2
UniProt:Q1KMD3 HNRL2			0.527	2
UniProt:Q9Y2R9 MRPS7	1	MRPS7 [mitochondrial inner membrane] (R-HSA-5368191)	0.527	2
UniProt:P08865 RPSA	2	RPSA [cytosol] (R-HSA-72389) RPSA [nucleoplasm] (R-HSA-6798722)	0.527	3
UniProt:Q96DV4 MRPL38	1	MRPL38 [mitochondrial inner membrane] (R-HSA-5368202)	0.527	2
UniProt:Q8WWM7 ATX2L			0.527	2
UniProt:Q9BZE1 MRPL37	1	MRPL37 [mitochondrial inner membrane] (R-HSA-5368240)	0.527	2
UniProt:O60812 HNRC1			0.527	3
UniProt:Q8TCC3 MRPL30	1	MRPL30 [mitochondrial inner membrane] (R-HSA-5368184)	0.527	3
UniProt:Q15020 SART3			0.527	3
UniProt:Q9Y6G3 MRPL42	1	MRPL42 [mitochondrial inner membrane] (R-HSA-5368237)	0.527	2
UniProt:Q9NX20 MRPL16	1	MRPL16 [mitochondrial inner membrane] (R-HSA-5368216)	0.527	2
UniProt:Q92900 UPF1	2	p-4S-UPF1 [cytosol] (R-HSA-927856) UPF1 [cytosol] (R-HSA-927734)	0.527	2
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.527	3
UniProt:Q9NQ50 MRPL40	1	MRPL40 [mitochondrial inner membrane] (R-HSA-5368222)	0.527	2
UniProt:Q9NRX2 MRPL17	1	MRPL17 [mitochondrial inner membrane] (R-HSA-5368217)	0.527	2
UniProt:Q96KR1 ZFR			0.527	2
UniProt:Q13405 MRPL49	1	MRPL49 [mitochondrial inner membrane] (R-HSA-5368260)	0.527	2
UniProt:Q8TAE8 GADD45GIP1	1	GADD45GIP1 [mitochondrial matrix] (R-HSA-5368253)	0.527	2
UniProt:Q9NZM5 NOP53			0.527	2
UniProt:P33469 NCAP			0.527	3
UniProt:O75534 CSDE1			0.527	2
UniProt:P52815 MRPL12	2	MRPL12 [mitochondrial inner membrane] (R-HSA-5368256) MRPL12 [mitochondrial matrix] (R-HSA-9839674)	0.527	2
UniProt:Q9H0U6 MRPL18	1	MRPL18 [mitochondrial inner membrane] (R-HSA-5368207)	0.527	2
UniProt:Q15527 SURF2			0.527	3
UniProt:Q7RTS1 BHLHA15	1	BHLHA15 [nucleoplasm] (R-HSA-9922593)	0.527	4
UniProt:Q92615 LAR4B			0.527	3
UniProt:Q66K89 E4F1			0.527	2
UniProt:Q9BYD2 MRPL9	1	MRPL9 [mitochondrial inner membrane] (R-HSA-5368262)	0.527	2
UniProt:Q92665 MRPS31	1	MRPS31 [mitochondrial inner membrane] (R-HSA-5368198)	0.527	2
UniProt:Q9UL18 AGO1	2	EIF2C1 [nucleoplasm] (R-HSA-5578686) EIF2C1 [cytosol] (R-HSA-210616)	0.527	4
UniProt:Q9P015 MRPL15	1	MRPL15 [mitochondrial inner membrane] (R-HSA-5368193)	0.527	2
UniProt:Q13310 PABP4			0.527	2
UniProt:Q9BYD1 MRPL13	1	MRPL13 [mitochondrial inner membrane] (R-HSA-5368244)	0.527	3
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.527	2
UniProt:Q9NZB2 F120A			0.527	2
UniProt:Q659C4 LAR1B			0.527	2
UniProt:Q92552 MRPS27	1	MRPS27 [mitochondrial inner membrane] (R-HSA-5368214)	0.527	2
UniProt:O75127 PTCD1			0.527	2
UniProt:Q8TBF4 ZCRB1	2	ZCRB1 [cytosol] (R-HSA-9682010) ZCRB1 [nucleoplasm] (R-HSA-6787853)	0.527	2
UniProt:O95758 PTBP3			0.527	2
UniProt:Q9NXG2 THUMPD1	1	THUMPD1 [nucleoplasm] (R-HSA-6791004)	0.527	3
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.527	2
UniProt:Q13601 KRR1	1	KRR1 [nucleoplasm] (R-HSA-6790611)	0.527	3
UniProt:P62241 RPS8	2	RPS8 [cytosol] (R-HSA-72385) RPS8 [nucleoplasm] (R-HSA-6791203)	0.527	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:P15880 RPS2	3	RPS2 [cytosol] (R-HSA-72347) Me2aR-RPS2 [cytosol] (R-HSA-8879138) RPS2 [nucleoplasm] (R-HSA-6790655)	0.527	3
UniProt:P16104 H2AFX	7	H2AFX [nucleoplasm] (R-HSA-56151) p-Y143-H2AFX [nucleoplasm] (R-HSA-5683942) p-S140,Y143-H2AFX [nucleoplasm] (R-HSA-5683953) p-S140-H2AFX [nucleoplasm] (R-HSA-75170) K63PolyUb-K14,K16,p-S140-H2AFX [nucleoplasm] (R-HSA-5682847) H2AFX [extracellular region] (R-HSA-977583) Me2sR4-H2AFX [nucleoplasm] (R-HSA-5218317)	0.527	4
UniProt:Q9UKV8 AGO2	2	AGO2 [cytosol] (R-HSA-209723) AGO2 [nucleoplasm] (R-HSA-5578701)	0.527	3
UniProt:P38919 EIF4A3	2	EIF4A3 [nucleoplasm] (R-HSA-8849149) EIF4A3 [cytosol] (R-HSA-927868)	0.527	2
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	2
UniProt:P62847 RPS24	2	RPS24 [cytosol] (R-HSA-72355) RPS24 [nucleoplasm] (R-HSA-6791186)	0.527	2
UniProt:Q15646 OASL	1	OASL [cytosol] (R-HSA-1015678)	0.527	2
IntAct:EBI-5333277 DSDNA			0.499	4
IntAct:EBI-5333321 DSDNA			0.499	3
UniProt:Q8NC51 SERB1			0.499	2
IntAct:EBI-5333296 DSDNA			0.499	2
UniProt:O75526 RMXL2			0.499	2
UniProt:Q99697 PITX2	1	PITX2 [nucleoplasm] (R-HSA-8864726)	0.499	3
UniProt:P12956 XRCC6	5	XRCC6 [nucleoplasm] (R-HSA-58272) XRCC6 [cytosol] (R-HSA-3134813) XRCC6 [secretory granule lumen] (R-HSA-6801312) XRCC6 [extracellular region] (R-HSA-6806444) XRCC6 [ficolin-1-rich granule lumen] (R-HSA-6801300)	0.483	2
UniProt:Q8IUH3 RBM45			0.462	2

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