SMAD7 binds SERPINE1 gene promoter

Stable Identifier
R-HSA-9736966
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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SMAD7 binds SERPINE1 gene promoter
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SMAD7 can bind the SERPINE1 (PAI-1) gene promoter (and probably other TGF-beta-responsive promoters) and inhibit PAI-1 expression by competing with SMAD2,3:SMAD4 binding (Zhang et al. 2007).
Literature References
PubMed ID Title Journal Year
17438144 Smad7 antagonizes transforming growth factor beta signaling in the nucleus by interfering with functional Smad-DNA complex formation

Zhang, L, Feng, XH, Chen, YG, Zhang, S, Ning, Y, Zhang, R, Fei, T, Chen, F, Meng, A, Han, Y

Mol. Cell. Biol. 2007
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Authored
Orlic-Milacic, M  (2012-04-05)
Reviewed
Huang, T  (2012-05-14)
Contreras, O  (2022-05-02)
Chen, YG  (2012-11-14)
Created
Orlic-Milacic, M  (2021-07-15)
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