Reactome | ORC1 binds to H4K20me2

ORC1 binds to H4K20me2

Stable Identifier

R-HSA-9749197

Type

Reaction [binding]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Besides binding to nucleosome-free replication origin DNA, ORC1 interacts with neighboring nucleosomes (Hizume et al. 2013). The interaction of ORC1 with nucleosomes may require specific epigenetic marks on nucleosomes, and may be disrupted by ORC1 mutations associated with the Meier-Gorlin Syndrome (Zhang et al. 2015). In particular, a bromo adjacent homology (BAH) domain of ORC1 has been shown to bind to histone H4 dimethylated at lysine 21 (H4K20me2 mark), which is enriched at replication origins. Binding of ORC1 to H4K20me2 facilitates ORC1 binding to replication origins and ORC chromatin loading (Kuo et al. 2012, Zhang et al. 2015).

Literature References

PubMed ID	Title	Journal	Year
25689043	A Meier-Gorlin syndrome mutation impairs the ORC1-nucleosome association Song, J, Gozani, O, Zhang, W, Sankaran, S	ACS Chem Biol	2015
22398447	The BAH domain of ORC1 links H4K20me2 to DNA replication licensing and Meier-Gorlin syndrome Song, J, Gozani, O, Patel, DJ, Cheung, P, Chen, JK, Yamazoe, S, Ishibe-Murakami, S, Kuo, AJ	Nature	2012