Formation of MCM2-7 complex

Stable Identifier
Reaction [binding]
Homo sapiens
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Six homologous minichromosome maintenance proteins, MCM2, MCM3, MCM4, MCM5, MCM6 and MCM7, form the evolutionarily conserved MCM2-7 complex, which functions as the core eukaryotic replicated DNA helicase. The structure of the complex is conserved from yeast (Li et al. 2015) to humans (Boskovic et al. 2016), representing an open hexameric ring, with a gate between subunits MCM2 and MCM5. The gate is thought to close and open the MCM2-7 ring to encircle DNA. Each MCM subunit contains an N-terminal DNA interacting and assembly domain and a C-terminal ATP-binding domain.
Literature References
PubMed ID Title Journal Year
27249176 Molecular architecture of the recombinant human MCM2-7 helicase in complex with nucleotides and DNA

Saligram Prabhakar, B, Méndez, J, Boskovic, J, Montoya, G, Bragado-Nilsson, E, Martínez-Gago, J, Yefimenko, I, Muñoz, S

Cell Cycle 2016
26222030 Structure of the eukaryotic MCM complex at 3.8 Å

Yang, M, Gao, N, Tye, BK, Zhai, Y, Li, N, Lei, J, Zhang, Y, Li, W

Nature 2015
Orthologous Events
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