LRRC14 binds IKBKB and CHUK

Stable Identifier
R-HSA-9749505
Type
Reaction [binding]
Species
Homo sapiens
Compartment
Synonyms
LRRC14 binds IKBKB and IKBKA
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Leucine-rich repeat-containing protein 14 (LRRC14) binds to the helix-loop-helix (HLH) domain of IKBKB (Wu C et al. 2016). This binding blocks IKBKB interaction with IKBKG (NEMO) disrupting IκB kinase (IKK) complex formation and NF-kappa-B activation (Wu C et al. 2016).
Literature References
PubMed ID Title Journal Year
27426725 LRRC14 attenuates Toll-like receptor-mediated NF-κB signaling through disruption of IKK complex

Cui, J, Ou, J, Wu, C, Yang, Y, Zhao, W, Zhu, L

Exp Cell Res 2016
Participants
Participates
Event Information
Orthologous Events
Authored
Reviewed
Created
Cite Us!