Reactome | K63polyUb-NLRX1 [cytosol]

K63polyUb-NLRX1 [cytosol]

Stable Identifier

R-HSA-9749510

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

NLR family member X1, NLRX1_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P49411 TUFM

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-1 family signaling (Homo sapiens)
      - Interleukin-1 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        TAK1-dependent IKK and NF-kappa-B activation (Homo sapiens)
        
        Regulation of NF-kappa B signaling (Homo sapiens)
        
        NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)
        
        K63polyUb-NLRX1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86UT6 NLRX1

Gene Names

NLRX1, NOD26, NOD5, NOD9

Chain

transit peptide:1-86, chain:87-975

Reference Genes

BioGPS Gene:79671 NLRX1

COSMIC (genes):NLRX1 NLRX1

CTD Gene:79671 NLRX1

dbSNP Gene:79671 NLRX1

ENSEMBL:ENSG00000160703 NLRX1

HGNC:29890 NLRX1

KEGG:hsa:79671 NLRX1

Monarch:79671 NLRX1

NCBI Gene:79671 NLRX1

OMIM:611947 NLRX1

UCSC:Q86UT6 NLRX1

Reference Transcript

Other Identifiers

11735428_a_at

11749092_a_at

11749133_a_at

1553695_PM_a_at

1553695_a_at

16732248

219680_PM_at

219680_at

3352001

3352003

3352004

3352005

3352006

3352007

3352008

3352009

3352010

3352012

3352013

3352014

3352015

3352016

3352017

3352018

3352019

3352020

3352021

3352022

3352023

3352024

3352025

3352026

3352027

3352028

3352029

3352030

3352033

3352034

3352035

3352036

3352037

3352038

3352039

45878_at

7944463

79671

A_14_P122934

A_24_P244356

GE82881

GO:0002376

GO:0005515

GO:0005524

GO:0005739

GO:0005741

GO:0005829

GO:0005886

GO:0010936

GO:0032688

GO:0032715

GO:0039536

GO:0043124

GO:0043226

GO:0045087

GO:0045824

GO:0050728

GO:0098542

HMNXSV003047922

Hs2.31097.2.S1_3p_s_at

ILMN_1698752

ILMN_1723768

PH_hs_0002655

TC11001087.hg

g13375837_3p_at

Participates

as a component of

CHUK:IKBKB:IKBKG:K63polyUb-NLRX1 [cytosol] (Homo sapiens)

as an input of

NLRX1 binds CHUK:IKBKB:IKBKG (Homo sapiens)

Other forms of this molecule

NLRX1 [mitochondrial outer membrane]

Inferred To

Homologues of K63polyUb-NLRX1 [cytosol] (Dictyostelium discoideum)

NLRX1 [cytosol] (Bos taurus)

NLRX1 [cytosol] (Canis familiaris)

K63polyUb-NLRX1 [cytosol] (Dictyostelium discoideum)

K63polyUb-NLRX1 [cytosol] (Gallus gallus)

K63polyUb-NLRX1 [cytosol] (Mus musculus)

K63polyUb-NLRX1 [cytosol] (Rattus norvegicus)

nlrx1 [cytosol] (Danio rerio)

nlrx1 [cytosol] (Xenopus tropicalis)

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [cytosol]) at unknown position

Modification

K63polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_011541282.1, NP_001269287.1, NP_078894.2, XP_005271726.1, NP_001269073.1, NP_001269072.1, XP_006718967.1

Guide to Pharmacology - Targets

1766

OpenTargets

ENSG00000160703

ENSEMBL

ENSP00000386851, ENSP00000433442, ENST00000525863, ENST00000409109, ENST00000292199, ENSP00000387334, ENST00000409991, ENST00000706729, ENSP00000292199, ENSP00000516519

HPA

ENSG00000160703-NLRX1

PRO

Q86UT6

Pharos - Targets

Q86UT6

PDB

3UN9

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P0DTD3 ORF9C			0.527	2
UniProt:P49411 TUFM	2	TUFM [mitochondrial matrix] (R-HSA-5389846) TUFM [mitochondrial outer membrane] (R-HSA-9754777)	0.499	2
UniProt:Q6PDS3	1	SARM-1 [cytosol] (R-MMU-2559572)	0.499	2