ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA

Stable Identifier
R-HSA-9749971
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
2,5-DHBA + Coenzyme A + ATP => 2,5-DHBA-CoA + AMP + pyrophosphate, 2,5-DHBA and Coenzyme A react to form 2,5-DHBA-CoA thioester
ReviewStatus
5/5
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ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
ACSM2B-like enzymes catalyze the transfer of acyl groups onto CoA (Vessey et al, 1976). This is a necessary step for conjugation of 2,5-DHBA with glycine (Wilson et al., 1978).
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as an event of
Catalyst Activity

CoA-ligase activity of ACSM2B-like proteins [mitochondrial matrix]

Physical Entity
ACSM2B-like proteins [mitochondrial matrix] (Homo sapiens)
Activity
CoA-ligase activity (GO:0016405)
Orthologous Events
ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Bos taurus)
ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Canis familiaris)
ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Danio rerio)
ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Gallus gallus)
ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Mus musculus)
ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Rattus norvegicus)
ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Sus scrofa)
ACSM2B-like proteins transform 2,5-DHBA to 2,5-DHB-CoA (Xenopus tropicalis)
Authored
Stephan, R  (2021-08-17)
Reviewed
Huddart, R  (2021-10-13)
Created
Stephan, R  (2021-08-09)
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