UGT1A6 glucuronates ST

Stable Identifier
R-HSA-9749977
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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A side effect of phenolic glucuronidation of salicylate (ST) (resulting in the O-glucuronide) is acyl glucuronation. In particular UGT1A6 glucuronates ST preferentially at the carboxyl group (Hutt et al, 1986; Iyanagi, 2007; Kuehl et al, 2006).
Literature References
PubMed ID Title Journal Year
16258079 Glucuronidation of the aspirin metabolite salicylic acid by expressed UDP-glucuronosyltransferases and human liver microsomes

Kuehl, GE, Potter, JD, Lampe, JW, Bigler, J

Drug Metab Dispos 2006
17482904 Molecular mechanism of phase I and phase II drug-metabolizing enzymes: implications for detoxification

Iyanagi, T

Int Rev Cytol 2007
3705620 The metabolism of aspirin in man: a population study

Smith, RL, Caldwell, J, Hutt, AJ

Xenobiotica 1986
Participants
Participates
Catalyst Activity

glucuronosyltransferase activity of UGT1A6 [endoplasmic reticulum membrane]

Orthologous Events
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