Reactome | ALB binds ST

ALB binds ST

Stable Identifier

R-HSA-9750666

Type

Reaction [transition]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Salicylate binds albumin

ReviewStatus

5/5

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Salicylate binds to multiple sites on serum albumin, but at therapeutic doses only one site seems relevant, for kinetic reason. The exact binding site is unknown. The binding is reversible (Reynolds & Cluff, 1960; Borgå et al, 1976; Shen et al, 1991).

Literature References

PubMed ID	Title	Journal	Year
975718	Protein binding of salicylate in uremic and normal plasma Borgå, O, Cederlöf, IO, Ringberger, VA, Norlin, A	Clin Pharmacol Ther	1976
13741103	Interaction of serum and sodium salicylate: changes during acute infection and its influence on pharmacological activity REYNOLDS, RC, CLUFF, LE	Bull Johns Hopkins Hosp	1960
1783992	Model representation of salicylate pharmacokinetics using unbound plasma salicylate concentrations and metabolite urinary excretion rates following a single oral dose Shen, J, Wanwimolruk, S, Purves, RD, McQueen, EG, Roberts, MS	J Pharmacokinet Biopharm	1991