TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex

Stable Identifier
R-HSA-975118
Type
Reaction [omitted]
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Compartment
endosome membrane, cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
TRAF6 ubiquitinqtes IRF7 within the activated TLR7/8 or 9 complex
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

TRAF6 E3 ubiquitin ligase activity was shown to be essential for IRF7 activation, although the role of TRAF6-dependent ubiquitination remains unclear [Kawai T et al 2004]. It has been demonstrated that IRF7 is ubiquitinated by TRAF6 at multiple sites both in vitro and in vivo[Ning et al 2008].It has been also shown that K63-linked ubiquitination of IRF7 is independent of its C-terminal functional phosphorylation sites.

Literature References
PubMed ID Title Journal Year
18710948 TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1

Bentz, GL, Ning, S, Pagano, JS, Darnay, BG, Campos, AD

Mol Cell Biol 2008
15361868 Interferon-alpha induction through Toll-like receptors involves a direct interaction of IRF7 with MyD88 and TRAF6

Kawai, T, Takeuchi, O, Inoue, J, Matsuda, M, Terai, K, Ishii, KJ, Sato, S, Yamamoto, M, Akira, S, Uematsu, S, Coban, C, Hemmi, H

Nat Immunol 2004
Participants
Input
Output
Participates
as an event of
Catalyst Activity

ubiquitin-protein transferase activity of IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane]

Physical Entity
IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9 [endosome membrane] (Homo sapiens)
Activity
ubiquitin-protein transferase activity (GO:0004842)
Authored
Shamovsky, V  (2010-08-25)
Reviewed
Gillespie, ME  (2010-10-29)
Created
Shamovsky, V  (2010-09-22)
Cite Us!