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p-IRAK2:oligo-TRAF6 [endosome membrane]
Stable Identifier
R-HSA-975137
Type
Complex
Species
Homo sapiens
Compartment
endosome membrane
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-1 Infection (Homo sapiens)
SARS-CoV-1-host interactions (Homo sapiens)
SARS-CoV-1 activates/modulates innate immune responses (Homo sapiens)
SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling) (Homo sapiens)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Homo sapiens)
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Homo sapiens)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
IRAK2 mediated activation of TAK1 complex upon TLR7/8 or 9 stimulation (Homo sapiens)
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Homo sapiens)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
p-IRAK2:oligo-TRAF6 [endosome membrane] (Homo sapiens)
Participants
components
x 2
TRAF6 [endosome membrane]
(Homo sapiens)
TRAF6:p-IRAK2 [endosome membrane]
(Homo sapiens)
Participates
as an output of
SARS-CoV-1 nsp3 deubiquinates K63-linked pUb oligo-TRAF6 (TLR7/8 signaling) (Homo sapiens)
IRAK2 induces TRAF6 oligomerization initiated from endosomal compartments (Homo sapiens)
as an input of
Auto ubiquitination of oligo-TRAF6 bound to p-IRAK2 at endosome membrane (Homo sapiens)
Inferred To
p-IRAK2:oligo-TRAF6 [endosome membrane]
(Bos taurus)
p-IRAK2:oligo-TRAF6 [endosome membrane]
(Canis familiaris)
p-IRAK2:oligo-TRAF6 [endosome membrane]
(Drosophila melanogaster)
p-IRAK2:oligo-TRAF6 [endosome membrane]
(Gallus gallus)
p-IRAK2:oligo-TRAF6 [endosome membrane]
(Mus musculus)
p-IRAK2:oligo-TRAF6 [endosome membrane]
(Rattus norvegicus)
p-IRAK2:oligo-TRAF6 [endosome membrane]
(Sus scrofa)
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