TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation

Stable Identifier
R-HSA-975138
Type
Pathway
Species
Homo sapiens
Related Species
Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2
Compartment
ReviewStatus
5/5
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TRAF6 mediates NFkB activation via canonical phosphorylation of IKK complex by TAK1. TRAF6 and TAK1 also regulate MAPK cascades leading to the activation of AP-1.
Literature References
PubMed ID Title Journal Year
22511786 Essential role for IKK? in production of type 1 interferons by plasmacytoid dendritic cells

Shpiro, N, Pauls, E, Sorcek, RJ, Cohen, P, Peggie, M, Young, ER, Choi, HG, Tan, L

J. Biol. Chem. 2012
18794297 The kinase activity of IL-1 receptor-associated kinase 4 is required for interleukin-1 receptor/toll-like receptor-induced TAK1-dependent NFkappaB activation

Kim, TW, Li, X, Wen, Q, Li, Y, Xiao, H, Yao, J, Casanova, JL, Fraczek, J, Pryjma, J

J. Biol. Chem. 2008
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