Reactome | K63polyUb-IRF7 [endosome membrane]

K63polyUb-IRF7 [endosome membrane]

Stable Identifier

R-HSA-975154

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endosome membrane

Synonyms

K63-linked polyUb-IRF7

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
18710948	TRAF6 and the three C-terminal lysine sites on IRF7 are required for its ubiquitination-mediated activation by the tumor necrosis factor receptor family member latent membrane protein 1 Bentz, GL, Ning, S, Pagano, JS, Darnay, BG, Campos, AD	Mol Cell Biol	2008

External Reference Information

External Reference

UniProt:Q92985 IRF7

Gene Names

IRF7

Chain

chain:1-503

Reference Genes

BioGPS Gene:3665 IRF7

COSMIC (genes):IRF7 IRF7

CTD Gene:3665 IRF7

dbSNP Gene:3665 IRF7

ENSEMBL:ENSG00000185507 IRF7

HGNC:6122 IRF7

KEGG:hsa:3665 IRF7

Monarch:3665 IRF7

NCBI Gene:3665 IRF7

OMIM:605047 IRF7

UCSC:Q92985 IRF7

Reference Transcript

Other Identifiers

11718916_a_at

16733995

208436_PM_s_at

208436_s_at

3358173

3358175

3358176

3358177

3358178

3358179

3358180

3358181

3358182

3358183

3358184

3358185

3358186

3358187

3358188

3358189

3358190

3358191

3358192

3358193

3358194

3358195

3358196

3358197

3358198

3358199

3358200

36412_s_at

3665

43350_f_at

74528_s_at

7945462

A_24_P118892

A_24_P378019

GE54698

GO:0000122

GO:0000785

GO:0000976

GO:0000978

GO:0000981

GO:0000987

GO:0002376

GO:0002753

GO:0002819

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006357

GO:0006974

GO:0009615

GO:0010008

GO:0010468

GO:0016064

GO:0019043

GO:0032479

GO:0032481

GO:0032727

GO:0032728

GO:0034124

GO:0034127

GO:0039530

GO:0043226

GO:0045087

GO:0045655

GO:0045893

GO:0045944

GO:0050776

GO:0051607

GO:0060337

GO:0060340

GO:0098542

GO:0140110

GO:1990837

GO:2000110

HMNXSV003008948

ILMN_1674646

ILMN_1798181

ILMN_2349061

PH_hs_0010006

TC11001241.hg

U53830_at

g4809285_3p_s_at

Participates

as a component of

K63-linked poly-Ub-IRF7:TRAF6:p-3S,3T-IRAK1:p-S,2T-IRAK4:oligo-MyD88:activated TLR7/8 or 9. [endosome membrane] (Homo sapiens)

Other forms of this molecule

IRF7 [cytosol]

p-S477,S479-IRF7 [cytosol]

p-S477,S479-IRF7 [nucleoplasm]

IRF7 [endosome membrane]

Modified Residues

Name

ubiquitinylated lysine (K63polyUb [endosome membrane]) at unknown position

Modification

K63polyUb [endosome membrane]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

XP_005252963.1, NP_001563.2, NP_004020.1, XP_016873163.1, NP_004022.2

OpenTargets

ENSG00000185507

ENSEMBL

ENST00000634105, ENST00000621391, ENSP00000434009, ENST00000525445, ENST00000612534, ENST00000633274, ENSP00000433903, ENST00000397566, ENSP00000488591, ENST00000330243, ENSP00000488581, ENST00000469048, ENST00000533182, ENSP00000479615, ENST00000348655, ENST00000633943, ENSP00000434607, ENST00000632827, ENSP00000380697, ENSP00000329411, ENSP00000488666, ENSP00000488039, ENSP00000480358, ENSP00000331803

HPA

ENSG00000185507-IRF7

PRO

Q92985

Pharos - Targets

Q92985

GlyGen

Q92985

Orphanet

IRF7

HMDB Protein

HMDBP13795

PDB

2O61

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9BVS5 TRMT61B	1	TRMT61B [mitochondrial matrix] (R-HSA-6787512)	0.623	3
UniProt:P29128 ICP0			0.556	5
UniProt:F5HDE4 ORF45			0.508	3
UniProt:Q9UHD2 TBK1	5	p-S172-TBK1 [cytosol] (R-HSA-168379) TBK1 [cytosol] (R-HSA-166267) K63polyUb-K30,K401-TBK1 [cytosol] (R-HSA-9730430) p-TBK1 [cytosol] (R-HSA-9008705) pS-172,K48polyUb-TBK1 [cytosol] (R-HSA-3249397)	0.508	2
UniProt:O00170 AIP	2	AIP [nucleoplasm] (R-HSA-8937156) AIP [cytosol] (R-HSA-8936839)	0.499	2
UniProt:P51617 IRAK1	14	IRAK1 [cytosol] (R-HSA-446639) p-2S,S376,T,T209,T387-IRAK1 [cytosol] (R-HSA-446682) p-2S,S376,T,T209,T387-IRAK1 [plasma membrane] (R-HSA-937011) p-T209,T387-IRAK1 [plasma membrane] (R-HSA-166279) p-T209-IRAK1 [plasma membrane] (R-HSA-937031) IRAK1 [plasma membrane] (R-HSA-937045) p-2S,S376,T,T209,T387-IRAK1 [endosome membrane] (R-HSA-975157) IRAK1 [endosome membrane] (R-HSA-975127) p-T209,T387-IRAK1 [endosome membrane] (R-HSA-975117) p-T209-IRAK1 [endosome membrane] (R-HSA-975189) K63polyUb-hp-IRAK1 [cytosol] (R-HSA-451565) p-S376,T387-IRAK1 [cytosol] (R-HSA-446687) K63polyUb-hp-IRAK1 [endosome membrane] (R-HSA-975112) p-S,T-IRAK1 [cytosol] (R-HSA-3149574)	0.499	2
UniProt:Q96A33 CCD47			0.499	2
UniProt:Q9ULE6 PALD			0.499	2
UniProt:Q86UE8 TLK2			0.499	2
UniProt:O94822 LTN1	1	LTN1 [cytosol] (R-HSA-5688967)	0.499	2
UniProt:P10398 ARAF	4	p-S299,S302,T452,T455,S582 ARAF [cytosol] (R-HSA-5672646) p-S299,S302,T452,T455,S582 ARAF [plasma membrane] (R-HSA-5672648) p-S582 ARAF [cytosol] (R-HSA-5672681) p-S214,S582 ARAF [cytosol] (R-HSA-5672639)	0.499	2