Reactome | MyD88 dependent cascade initiated on endosome

MyD88 dependent cascade initiated on endosome

Stable Identifier

R-HSA-975155

Type

Pathway

Species

Homo sapiens

Related Species

Severe acute respiratory syndrome coronavirus 2, Human SARS coronavirus, Influenza A virus, Human immunodeficiency virus 1

Compartment

cytosol, endosome membrane, nucleoplasm

ReviewStatus

5/5

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MyD88 dependent cascade initiated on endosome

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Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Literature References

PubMed ID	Title	Journal	Year
15276183	MD-2: the Toll 'gatekeeper' in endotoxin signalling Gay, NJ, Gangloff, M	Trends Biochem Sci	2004
18652679	Comparison of human B cell activation by TLR7 and TLR9 agonists Lipson, KE, Hanten, JA, Riter, CL, Birmachu, W, Neys, L, Vasilakos, JP, Alkan, SS	BMC Immunol.	2008
20237413	Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance Cherfils-Vicini, J, Sautès-Fridman, C, Gillard, M, Damotte, D, Validire, P, Fridman, WH, Dieu-Nosjean, MC, Platonova, S, Cremer, I, Laurans, L, Mami-Chouaib, F, Caliandro, R, Magdeleinat, P	J. Clin. Invest.	2010