Reactome | MyD88 dependent cascade initiated on endosome

MyD88 dependent cascade initiated on endosome

Stable Identifier

R-HSA-975155

Type

Pathway

Species

Homo sapiens

Related Species

Severe acute respiratory syndrome coronavirus 2, Human SARS coronavirus, Influenza A virus, Human immunodeficiency virus 1

Compartment

cytosol, endosome membrane, nucleoplasm

ReviewStatus

5/5

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MyD88 dependent cascade initiated on endosome

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Upon binding of their ligands, TLR7/8 and TLR9 recruit a cytoplasmic adaptor MyD88 and IRAKs, downstream of which the signaling pathways are divided to induce either inflammatory cytokines or type I IFNs.

Literature References

PubMed ID	Title	Journal	Year
15276183	MD-2: the Toll 'gatekeeper' in endotoxin signalling Gangloff, M, Gay, NJ	Trends Biochem Sci	2004
18652679	Comparison of human B cell activation by TLR7 and TLR9 agonists Hanten, JA, Vasilakos, JP, Riter, CL, Neys, L, Lipson, KE, Alkan, SS, Birmachu, W	BMC Immunol.	2008
20237413	Triggering of TLR7 and TLR8 expressed by human lung cancer cells induces cell survival and chemoresistance Cherfils-Vicini, J, Platonova, S, Gillard, M, Laurans, L, Validire, P, Caliandro, R, Magdeleinat, P, Mami-Chouaib, F, Dieu-Nosjean, MC, Fridman, WH, Damotte, D, Sautès-Fridman, C, Cremer, I	J. Clin. Invest.	2010