Reactome | IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9

IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9

Stable Identifier

R-HSA-975170

Type

Reaction [transition]

Species

Homo sapiens

Related Species

Human immunodeficiency virus 1, Influenza A virus, Human SARS coronavirus, Severe acute respiratory syndrome coronavirus 2

Compartment

endosome membrane, cytosol

ReviewStatus

5/5

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IRAK4 autophosphorylation in the complex with MyD88:activated TLR 7/8 or 9

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IRAK4 is activated by autophosphorylation at 3 positions within the kinase activation loop, Thr-342, Thr-345 and Ser-346.

Literature References

PubMed ID	Title	Journal	Year
17485511	Essential role of IRAK-4 protein and its kinase activity in Toll-like receptor-mediated immune responses but not in TCR signaling Takeuchi, O, Yamamoto, M, Sato, S, Jung, A, Akira, S, Matsui, K, Kato, H, Uematsu, S, Kawagoe, T	J Exp Med	2007
17141195	Regulation of IRAK-4 kinase activity via autophosphorylation within its activation loop Dahlstrand, E, Wang, A, Ocain, TD, Li, Z, Addona, T, Xu, Y, Lu, C, Dorsch, M, Keshishian, H, Parsons, TF, Li, P, Jaffee, B, Cheng, H	Biochem Biophys Res Commun	2007