Reactome | KCNJ6 [plasma membrane]

KCNJ6 [plasma membrane]

Stable Identifier

R-HSA-975242

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

G protein-activated inward rectifier potassium channel 2, IRK6_HUMAN

Locations in the PathwayBrowser

Expand all

Neuronal System (Homo sapiens)

- Potassium Channels (Homo sapiens)
  - Inwardly rectifying K+ channels (Homo sapiens)
    - G protein gated Potassium channels (Homo sapiens)
      - Activation of G protein gated Potassium channels (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ6 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ6 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ6 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ6 [plasma membrane] (Homo sapiens)
- Transmission across Chemical Synapses (Homo sapiens)
  - Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
    - GABA receptor activation (Homo sapiens)
      - GABA B receptor activation (Homo sapiens)
        
        Activation of GABAB receptors (Homo sapiens)
        
        Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits (Homo sapiens)
        
        Activation of GIRK/Kir3 Channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ6 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ6 [plasma membrane] (Homo sapiens)
        
        Binding of Gbeta/gamma to GIRK/Kir3 channels (Homo sapiens)
        
        GABA B receptor G-protein beta-gamma and Kir3 channel complex [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ6 [plasma membrane] (Homo sapiens)
        
        Kir heterotetramers [plasma membrane] (Homo sapiens)
        
        Kir3 heterotetramer [plasma membrane] (Homo sapiens)
        
        Kir3.x channels [plasma membrane] (Homo sapiens)
        
        KCNJ6 [plasma membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P48051 KCNJ6

Gene Names

KCNJ6, GIRK2, KATP2, KCNJ7

Chain

chain:1-423

Reference Genes

BioGPS Gene:3763 KCNJ6

COSMIC (genes):KCNJ6 KCNJ6

CTD Gene:3763 KCNJ6

dbSNP Gene:3763 KCNJ6

ENSEMBL:ENSG00000157542 KCNJ6

HGNC:6267 KCNJ6

KEGG:hsa:3763 KCNJ6

Monarch:3763 KCNJ6

NCBI Gene:3763 KCNJ6

OMIM:600877 KCNJ6

UCSC:P48051 KCNJ6

Reference Transcript

RefSeq:NM_002240.4 KCNJ6

Other Identifiers

11733475_s_at

11733476_at

16925563

210454_PM_s_at

210454_s_at

232411_PM_at

232411_at

3515414

37435_s_at

3763

3931505

3931506

3931507

3931508

3931509

3931510

3931511

3931512

3931513

3931514

3931515

3931516

3931517

3931518

3931519

3931520

3931521

3931522

3931523

3931524

3931525

3931526

3931527

3931528

3931529

3931559

3931588

3931589

3931616

3931617

3931653

3931654

3931655

43892_at

8070279

8070286

A_23_P29057

A_32_P203688

GE53007

GE56407

GE566929

GE810545

GO:0005215

GO:0005242

GO:0005515

GO:0005794

GO:0005886

GO:0006813

GO:0008076

GO:0015467

GO:0016020

GO:0034220

GO:0034702

GO:0034765

GO:0043226

GO:0055085

GO:1990573

HMNXSV003024771

Hs.27261.0.S1_3p_at

ILMN_1805376

PH_hs_0002415

PH_hs_0028524

TC21000442.hg

TC21000443.hg

TC21000965.hg

TC21000966.hg

U52153_at

g1052874_3p_a_at

p26164

Participates

as a member of

Kir3.x channels [plasma membrane] (Homo sapiens)

Inferred To

irk-2 [plasma membrane] (Caenorhabditis elegans)

KCNJ6 [plasma membrane] (Bos taurus)

KCNJ6 [plasma membrane] (Canis familiaris)

KCNJ6 [plasma membrane] (Gallus gallus)

KCNJ6 [plasma membrane] (Sus scrofa)

Kcnj6 [plasma membrane] (Mus musculus)

Kcnj6 [plasma membrane] (Rattus norvegicus)

kcnj6 [plasma membrane] (Xenopus tropicalis)

Homologues of KCNJ6 [plasma membrane] (Caenorhabditis elegans)

Homologues of KCNJ6 [plasma membrane] (Drosophila melanogaster)

Irk1 [plasma membrane] (Drosophila melanogaster)

irk-3 [plasma membrane] (Caenorhabditis elegans)

Irk3 [plasma membrane] (Drosophila melanogaster)

irk-1 [plasma membrane] (Caenorhabditis elegans)

Irk2 [plasma membrane] (Drosophila melanogaster)

Cross References

Guide to Pharmacology - Targets

435

ENSEMBL

ENST00000645093, ENSP00000493772, ENST00000609713, ENSP00000477437

OpenTargets

ENSG00000157542

HPA

ENSG00000157542-KCNJ6

PRO

P48051

Pharos - Targets

P48051

Orphanet

KCNJ6

HMDB Protein

HMDBP08744

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q14162 SCARF1	2	SCARF1 [plasma membrane] (R-HSA-2197636) SCARF1 [endocytic vesicle membrane] (R-HSA-2239453)	0.556	3
UniProt:P05090 APOD	1	APOD [extracellular region] (R-HSA-5216199)	0.556	3
UniProt:Q01453 PMP22	1	PMP22 [plasma membrane] (R-HSA-9615623)	0.556	3
UniProt:Q9BT09 CNPY3	1	CNPY3 [endoplasmic reticulum lumen] (R-HSA-1678932)	0.556	3
UniProt:Q9Y5Z9 UBIAD1	1	UBIAD1 [endoplasmic reticulum membrane] (R-HSA-2980965)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.556	3
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [transport vesicle] (R-HSA-6808719) BET1 [Golgi membrane] (R-HSA-6807743)	0.556	3