GSTs transfer GSH to NAPQI to form APAP-SG

Stable Identifier
R-HSA-9753280
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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N-acetyl-p-benzoquinone imine (NAPQI) can bind to the cysteine thiol of GSH, a critical mechanism of detoxification. The reaction of NAPQI with GSH can occur both spontaneously and enzymatically (Coles et al. 1998).
Literature References
PubMed ID Title Journal Year
3395122 The spontaneous and enzymatic reaction of N-acetyl-p-benzoquinonimine with glutathione: a stopped-flow kinetic study

Wilson, I, Wardman, P, Nelson, SD, Hinson, JA, Coles, B, Ketterer, B

Arch Biochem Biophys 1988
Participants
Participates
Catalyst Activity

glutathione transferase activity of GSTM1,P1,T1 dimers [cytosol]

Orthologous Events
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