ABCC3,ABCC4 transport APAP-GlcA, APAP-SO3

Stable Identifier
R-HSA-9753283
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
Locations in the PathwayBrowser
General
SVG |   | PPTX  | SBGN
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Glucuronidated acetaminophen (APAP-GlcA) and sulfated acetaminophen (APAP-SO3) can also be secreted into blood via the ATP-binding cassette sub-family C member 3 and 4 transporters (ABCC3 and ABCC4), both found at the basolateral surface of hepatocytes (Giacomini et al. 2010, review McGill & Jaeschke 2013, Koenderink et al. 2020).
Literature References
PubMed ID Title Journal Year
32472168 Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

Bilos, A, Vredenburg, G, Russel, FGM, Vermeulen, NPE, Koenderink, JB, van den Heuvel, JJMW

Arch Toxicol 2020
20190787 Membrane transporters in drug development

Chu, X, Dahlin, A, Niemi, M, Ishikawa, T, Benet, LZ, Zhang, L, Wright, SH, Keppler, D, Brouwer, KL, Lee, CA, Kim, RB, Tweedie, DJ, Sugiyama, Y, Hillgren, KM, Swaan, PW, Giacomini, KM, Fischer, V, Evers, R, Yee, SW, Zamek-Gliszczynski, MJ, Ware, JA, Polli, JW, Hoffmaster, KA, Huang, SM

Nat Rev Drug Discov 2010
Participants
Participates
Catalyst Activity

ATPase-coupled transmembrane transporter activity of ABCC3, ABCC4 [plasma membrane]

Orthologous Events
Authored
Reviewed
Created
Cite Us!