Reactome | ACY1:Zn2+ dimer deacetylates NAC to L-Cys

ACY1:Zn2+ dimer deacetylates NAC to L-Cys

Stable Identifier

R-HSA-9753944

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ACY1:Zn2+ dimer deacetylates NAC to L-Cys

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The effects of paracetamol (APAP) poisoning can be reversed by administration of N-acetyl-L-cysteine (NAC) within 15hrs of APAP intake. This treatment is effective in preventing liver damage, hepatic failure, renal damage, and death (Prescott et al. 1977, Prescott 1981). NAC provides L-cysteine (L-Cys) for the formation of the tripeptide glutathione, which can conjugate the reactive APAP metabolite N-acetyl-p-benzoquinine imine (NAPQI), thereby reducing damage. NAC is thought to be deacetylated to L-Cys by aminocylase 1 (ACY1), a dimeric enzyme highly expressed in the kidneys (Stocker et al. 2012, review Pedre et al. 2021).

Literature References

PubMed ID	Title	Journal	Year
70646	Treatment of paracetamol (acetaminophen) poisoning with N-acetylcysteine Park, J, Proudfoot, AT, Adriaenssens, P, Ballantyne, A, Prescott, LF	Lancet	1977
22349737	Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides Perrier, J, Vidal, N, Giardina, T, Stocker, P, do Amaral, AT, Roche, P, de Rezende, L, Morelli, X, Brunel, JM	Biochimie	2012
7469630	Treatment of severe acetaminophen poisoning with intravenous acetylcysteine Prescott, LF	Arch Intern Med	1981