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TUFM [mitochondrial outer membrane]
Stable Identifier
R-HSA-9754777
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial outer membrane
Synonyms
Elongation factor Tu, mitochondrial, EFTU_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q00005 2ABB
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
SARS-CoV Infections (Homo sapiens)
SARS-CoV-2 Infection (Homo sapiens)
SARS-CoV-2-host interactions (Homo sapiens)
SARS-CoV-2 modulates autophagy (Homo sapiens)
SARS-CoV-2 M protein binds TUFM (Homo sapiens)
TUFM [mitochondrial outer membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P49411 TUFM
Gene Names
TUFM
Chain
transit peptide:1-46, chain:47-455
Reference Genes
BioGPS Gene:7284 TUFM
COSMIC (genes):TUFM TUFM
CTD Gene:7284 TUFM
dbSNP Gene:7284 TUFM
ENSEMBL:ENSG00000178952 TUFM
ENSEMBL_homo_sapiens_GENE:ENSG00000178952.11 TUFM
HGNC:12420 TUFM
KEGG Gene (Homo sapiens):7284 TUFM
Monarch:7284 TUFM
NCBI Gene:7284 TUFM
OMIM:602389 TUFM
UCSC:P49411 TUFM
Reference Transcript
RefSeq:NM_003321.4 TUFM
RefSeq:XM_017023619.1 TUFM
Other Identifiers
11715468_at
16825410
201113_PM_at
201113_at
238190_PM_at
238190_at
2890089
3686729
3686730
3686732
3686733
3686735
3686736
3686738
3686739
3686740
3686741
3686742
3686743
3686744
3750178
3750189
3750199
3750203
39867_at
7284
8000603
92041_at
GE58809
GO:0000166
GO:0003723
GO:0003746
GO:0003824
GO:0003924
GO:0005515
GO:0005525
GO:0005576
GO:0005615
GO:0005739
GO:0005741
GO:0006412
GO:0006414
GO:0016020
GO:0016787
GO:0042645
GO:0043226
GO:0045182
GO:0045202
GO:0045471
GO:0070062
GO:0070125
GO:0140053
HMNXSV003035927
HMNXSV003036684
Hs.171379.0.A1_3p_at
ILMN_1738369
PH_hs_0001135
PH_hs_0035348
S75463_at
TC16000994.hg
TC16001829.hg
g4507732_3p_at
Participates
as an input of
SARS-CoV-2 M protein binds TUFM (Homo sapiens)
as a component of
TUFM:M [endoplasmic reticulum membrane] (Homo sapiens)
Other forms of this molecule
TUFM [mitochondrial matrix]
Cross References
RefSeq
XP_016879108.1
,
NP_003312.3
OpenTargets
ENSG00000178952
GeneCards
P49411
HPA
ENSG00000178952-TUFM
Ensembl
ENST00000313511
,
ENSP00000322439
,
ENSG00000178952
PRO
P49411
Pharos - Targets
P49411
Orphanet
20154
HMDB Protein
HMDBP08372
PDB
7A5G
,
7O9K
Interactors (17)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q8IZU0 FAM9B
0.666
4
UniProt:P03427 PB2
0.599
9
UniProt:Q15041 AR6P1
0.556
3
UniProt:Q96DZ9 CKLF5
0.556
3
UniProt:Q8IVP5 FUNDC1
4
p-S17-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8948140)
p-S13,Y18-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934915)
FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934922)
p-S13-FUNDC1 [mitochondrial outer membrane]
(R-HSA-8934910)
0.556
3
UniProt:Q96RQ3 MCCC1
9
L437P Btn-MCCC1 [mitochondrial matrix]
(R-HSA-9908666)
V694* Btn-MCCC1 [mitochondrial matrix]
(R-HSA-9908683)
D532H Btn-MCCC1 [mitochondrial matrix]
(R-HSA-9908652)
M325R Btn-MCCC1 [mitochondrial matrix]
(R-HSA-9908669)
I460M Btn-MCCC1 [mitochondrial matrix]
(R-HSA-9908657)
R385S Btn-MCCC1 [mitochondrial matrix]
(R-HSA-9908676)
Btn-MCCC1 [cytosol]
(R-HSA-3323154)
MCCC1 [cytosol]
(R-HSA-3323164)
Btn-MCCC1 [mitochondrial matrix]
(R-HSA-70748)
0.527
2
UniProt:Q9UK85 DKKL1
0.527
3
UniProt:O95789 ZMYM6
0.527
2
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:Q01523 DEFA5
5
DEFA5(1-94) [Golgi lumen]
(R-HSA-1467267)
DEFA5(20-94) [Golgi lumen]
(R-HSA-1467208)
DEFA5(20-94) [secretory granule lumen]
(R-HSA-1471358)
DEFA5(20-94) [extracellular region]
(R-HSA-1471344)
DEFA5(?-94) [extracellular region]
(R-HSA-1462017)
0.527
2
UniProt:P46199 MTIF2
1
MTIF2 [mitochondrial matrix]
(R-HSA-5368271)
0.527
2
UniProt:Q8N307 MUC20
19
Core 8 (MUC20) [Golgi lumen]
(R-HSA-1462329)
Core 2S (MUC20) [Golgi lumen]
(R-HSA-6786382)
Core 5 (MUC20) [Golgi lumen]
(R-HSA-1462128)
Core 4 (MUC20) [Golgi lumen]
(R-HSA-1462266)
Core 3 (MUC20) [Golgi lumen]
(R-HSA-1462344)
Core 7 (MUC20) [Golgi lumen]
(R-HSA-1462236)
extended Core 6 (MUC20) [Golgi lumen]
(R-HSA-1967016)
Core 6 (MUC20) [Golgi lumen]
(R-HSA-1462247)
MUC20 [Golgi lumen]
(R-HSA-913634)
Disialyl T-antigen (MUC20) [Golgi lumen]
(R-HSA-1463482)
Sialyl T-antigen (MUC20) [Golgi lumen]
(R-HSA-1463469)
Sialyl-2,3 T-antigen (MUC20) [Golgi lumen]
(R-HSA-1463479)
T-antigen (MUC20) [Golgi lumen]
(R-HSA-1462188)
Sialyl Tn antigen (MUC20) [Golgi lumen]
(R-HSA-1463558)
GalNAc-MUC20 [Golgi lumen]
(R-HSA-1463443)
Core 2a (MUC20) [Golgi lumen]
(R-HSA-6784267)
Core 2 (MUC20) [Golgi lumen]
(R-HSA-1462330)
GalNAc-MUC20 [plasma membrane]
(R-HSA-8858516)
MUC20 [plasma membrane]
(R-HSA-8851833)
0.527
2
UniProt:Q86UT6 NLRX1
2
K63polyUb-NLRX1 [cytosol]
(R-HSA-9749510)
NLRX1 [mitochondrial outer membrane]
(R-HSA-936551)
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
UniProt:A0A096LP01 SIM26
0.462
2
UniProt:Q00005 2ABB
0.462
2
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