NT5C2 tetramer phosphorylates RBV

Stable Identifier
R-HSA-9754916
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Ribavirin (RBV) phosphorylation to ribavirin monophosphate (RBV-MP) can be catalyzed by the 5′-nucleotidase NT5C2, with a catalytic efficiency much better than that by adenosine kinase (ADK) (Wu et al, 2005). This appears to be the rate-limiting step in the intracellular ribavirin metabolism resulting in the triphosphate (Page and Connor, 1990; Wallden and Nordlund, 2011).

Literature References
Participants
Participates
Catalyst Activity

nucleoside phosphotransferase activity of NT5C2 tetramer [cytosol]

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