SLC29A3 transports RBV,RBV-TP from cytosol to mitochondrial matrix

Stable Identifier
Reaction [transition]
Homo sapiens
SLC29A3 imports RBV,RBV-TP to mitochondria
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Equilibrative nucleoside transporter 3 (ENT3, SLC29A3) is an intracellular transporter involved in mitochondrial import of ribavirin (RBV) and RBV-TP (Hu et al, 2006; Govindarajan et al, 2009). Mitochondrial import of RBV appears to be a factor contributing to mitochondrial toxicity in patients treated with both RBV and highly active antiretrovirals (HAART) (Reiberger et al, 2010).
Literature References
PubMed ID Title Journal Year
19164483 Facilitated mitochondrial import of antiviral and anticancer nucleoside drugs by human equilibrative nucleoside transporter-3

Wang, J, Unadkat, JD, Govindarajan, R, Tse, CM, Leung, GP, Zhou, M

Am J Physiol Gastrointest Liver Physiol 2009
20486858 Mitochondrial toxicity is associated with virological response in patients with HIV and hepatitis C virus coinfection treated with ribavirin and highly active antiretroviral therapy

Peck-Radosavljevic, M, Wrba, F, Gangl, A, Breitenecker, F, Kosi, L, Maresch, J, Reiberger, T, Payer, BA, Rieger, A

J Infect Dis 2010
16446384 Electrophysiological characterization and modeling of the structure activity relationship of the human concentrative nucleoside transporter 3 (hCNT3)

Swaan, PW, Lee, EW, Chang, C, Endres, CJ, Ganapathy, V, Umapathy, NS, Hu, H, Unadkat, JD, Itagaki, S, Fei, YJ

Mol Pharmacol 2006
Catalyst Activity

nucleoside transmembrane transporter activity of SLC29A3 [mitochondrial outer membrane]

Orthologous Events
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