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ub-UBXN7 [cytosol]
Stable Identifier
R-HSA-9755305
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
UBX domain-containing protein 7, UBXN7_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q8TAT6 NPLOC4
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
KEAP1-NFE2L2 pathway (Homo sapiens)
MUL1 ubiquitinates UBXN7 (Homo sapiens)
ub-UBXN7 [cytosol] (Homo sapiens)
ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
ub-UBXN7 [cytosol] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Neddylation (Homo sapiens)
MUL1 ubiquitinates UBXN7 (Homo sapiens)
ub-UBXN7 [cytosol] (Homo sapiens)
ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
ub-UBXN7 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O94888 WIPF1
Gene Names
WIPF1, UBXN7, KIAA0794, UBXD7
Chain
initiator methionine:, chain:2-489
Reference Genes
BioGPS Gene:26043 WIPF1
COSMIC (genes):UBXN7 WIPF1
COSMIC (genes):WIPF1 WIPF1
CTD Gene:26043 WIPF1
dbSNP Gene:26043 WIPF1
ENSEMBL:ENSG00000163960 WIPF1
HGNC:29119 WIPF1
KEGG:hsa:26043 WIPF1
Monarch:26043 WIPF1
NCBI Gene:26043 WIPF1
OMIM:616379 WIPF1
UCSC:O94888 WIPF1
Reference Transcript
RefSeq:NM_015562.1 WIPF1
Other Identifiers
11755885_a_at
11755910_a_at
11756796_a_at
16963338
16963340
212840_PM_at
212840_at
217100_PM_s_at
217100_s_at
26043
2712837
2712838
2712845
2712847
2712849
2712851
2712852
2712853
2712855
2712857
2712859
2712860
2712861
2712862
2712863
2712864
2712865
2712866
2712869
2712870
2712871
2712872
2712875
2712876
2712880
2712881
2712882
2712884
2712890
2712891
41691_at
68851_at
8093110
8093112
A_23_P358221
A_32_P222515
A_33_P3262292
GE53494
GO:0005515
GO:0005634
GO:0005654
GO:0005829
GO:0030163
GO:0031625
GO:0034098
GO:0043130
GO:0043161
GO:0043226
GO:0061629
HMNXSV003006614
Hs.127287.0.S1_3p_at
Hs.127287.1.S1_3p_a_at
ILMN_1733116
ILMN_1743594
PH_hs_0007300
TC03002158.hg
TC03002159.hg
Participates
as an input of
ub UBXN7 is degraded by the 26S proteasome (Homo sapiens)
as an output of
MUL1 ubiquitinates UBXN7 (Homo sapiens)
Other forms of this molecule
UBXN7 [cytosol]
Inferred To
ubxn7 [cytosol]
(Danio rerio)
Dmel\CG8892 [cytosol]
(Drosophila melanogaster)
UBX5 [cytosol]
(Saccharomyces cerevisiae)
ubx2 [cytosol]
(Schizosaccharomyces pombe)
ub-UBXN7 [cytosol]
(Gallus gallus)
ub-UBXN7 [cytosol]
(Plasmodium falciparum)
ubxd7 [cytosol]
(Dictyostelium discoideum)
UBXN7 [cytosol]
(Bos taurus)
UBXN7 [cytosol]
(Sus scrofa)
Ubxn7 [cytosol]
(Mus musculus)
AABR07034438.1 [cytosol]
(Rattus norvegicus)
Modified Residues
Name
ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at 14
Coordinate
14
Modification
K48-linked polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Name
ubiquitinylated lysine (K48-linked polyubiquitin chain [cytosol]) at 412
Coordinate
412
Modification
K48-linked polyubiquitin chain [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
ENSEMBL
ENSP00000296328
,
ENST00000296328
OpenTargets
ENSG00000163960
HPA
ENSG00000163960-UBXN7
PRO
O94888
Pharos - Targets
O94888
GlyGen
O94888
PDB
5X4L
,
5X3P
,
1WJ4
,
2DAL
,
2DLX
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P55072 VCP
8
VCP [cytosol]
(R-HSA-1181251)
VCP [secretory granule lumen]
(R-HSA-6801039)
VCP [extracellular region]
(R-HSA-6806191)
VCP [azurophil granule lumen]
(R-HSA-6800438)
VCP [ficolin-1-rich granule lumen]
(R-HSA-6800425)
VCP [nucleoplasm]
(R-HSA-5643745)
VCP [endoplasmic reticulum membrane]
(R-HSA-8943105)
Me3K315-VCP [cytosol]
(R-HSA-8932209)
0.821
19
UniProt:Q13617 CUL2
3
CUL2 [cytosol]
(R-HSA-416982)
CUL2 [nucleoplasm]
(R-HSA-1234126)
G76-NEDD8-K689-CUL2 [cytosol]
(R-HSA-8952511)
0.708
20
UniProt:Q13618 CUL3
3
G76-NEDD8-K712-CUL3 [cytosol]
(R-HSA-8952516)
CUL3 [nucleoplasm]
(R-HSA-5635033)
CUL3 [cytosol]
(R-HSA-975979)
0.623
6
UniProt:Q13619 CUL4A
2
CUL4A [nucleoplasm]
(R-HSA-976006)
G76-NEDD8-K705-CUL4A [nucleoplasm]
(R-HSA-8952514)
0.623
7
IntAct:EBI-4399559 UBIQ
0.591
5
UniProt:Q13616 CUL1
3
CUL1 [cytosol]
(R-HSA-174230)
CUL1 [nucleoplasm]
(R-HSA-187551)
G76-NEDD8-K720-CUL1 [cytosol]
(R-HSA-8952519)
0.564
8
UniProt:Q13620 CUL4B
2
CUL4B [nucleoplasm]
(R-HSA-975973)
G76-NEDD8-K859-CUL4B [nucleoplasm]
(R-HSA-8952522)
0.564
3
UniProt:Q9Y4K3 TRAF6
8
TRAF6 [cytosol]
(R-HSA-166366)
K63polyUb-TRAF6 [cytosol]
(R-HSA-2685681)
K63polyUb-TRAF6 [plasma membrane]
(R-HSA-936980)
TRAF6 [plasma membrane]
(R-HSA-936955)
K63polyUb-TRAF6 [endosome membrane]
(R-HSA-450227)
TRAF6 [endosome membrane]
(R-HSA-450272)
PolyUb-TRAF6 [cytosol]
(R-HSA-6782845)
K48polyUb-TRAF6 [cytosol]
(R-HSA-6783233)
0.556
3
UniProt:P26367 PAX6
1
PAX6 [nucleoplasm]
(R-HSA-3009044)
0.556
3
UniProt:Q02548 PAX5
1
PAX5 [nucleoplasm]
(R-HSA-158583)
0.556
3
UniProt:O43186 CRX
0.556
3
UniProt:A8MQ03 CRTP1
0.556
3
UniProt:Q9BVG3 TRIM62
1
TRIM62 [cytosol]
(R-HSA-5624340)
0.556
3
UniProt:P50221 MEOX1
0.556
3
UniProt:Q92567-2 FAM168A
0.556
3
UniProt:Q04864-2 REL
0.556
3
UniProt:Q13952-2 NFYC
0.556
3
UniProt:Q9UMX0 UBQLN1
1
UBQLN1 [cytosol]
(R-HSA-8866006)
0.556
3
UniProt:Q6UXS0 CL19A
0.556
3
UniProt:Q15038 DAZP2
0.556
3
UniProt:Q9BZR9 TRIM8
1
TRIM8 [cytosol]
(R-HSA-5624332)
0.556
3
UniProt:Q9HCM9-2 TRIM39
0.556
3
UniProt:Q8ND25 ZNRF1
1
ZNRF1 [cytosol]
(R-HSA-8850903)
0.556
5
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.556
3
UniProt:Q9BQ90 KLHDC3
1
KLHDC3 [cytosol]
(R-HSA-535552)
0.527
2
UniProt:Q9NS56 TOPORS
2
monoSUMO1-K560-TOPORS [nucleoplasm]
(R-HSA-4551754)
TOPORS [nucleoplasm]
(R-HSA-2993791)
0.527
2
UniProt:Q9H093 NUAK2
0.527
2
UniProt:Q96MN5 TEAN2
0.527
2
UniProt:Q9WTX6
3
Cul1 [cytosol]
(R-MMU-8952519)
Cul1 [nucleoplasm]
(R-MMU-187551)
Cul1 [cytosol]
(R-MMU-174230)
0.499
3
UniProt:Q15843 NEDD8
8
C111-AcM-UBE2M-G76-NEDD8 [nucleoplasm]
(R-HSA-8952504)
NEDD8 [nucleoplasm]
(R-HSA-8955926)
C111-AcM-UBE2M-G76-NEDD8 [cytosol]
(R-HSA-4419895)
NEDD8 [cytosol]
(R-HSA-416969)
C237-UBA3-G76-NEDD8 [cytosol]
(R-HSA-8951647)
NEDD8(1-81) [cytosol]
(R-HSA-5690794)
NEDD8(77-81) [cytosol]
(R-HSA-6782654)
C116-AcM-UBE2F-G76-NEDD8 [cytosol]
(R-HSA-8951739)
0.499
2
UniProt:Q16665 HIF1A
7
HIF1A [nucleoplasm]
(R-HSA-1234135)
HIF1A [cytosol]
(R-HSA-1234102)
p-Y565-HIF1A [cytosol]
(R-HSA-8857584)
p-Y565,S797-HIF1A [cytosol]
(R-HSA-9634700)
2xHP-HIF1A [cytosol]
(R-HSA-1234131)
2xHP-HIF1A [nucleoplasm]
(R-HSA-1234105)
HN-HIF1A [cytosol]
(R-HSA-1234110)
0.499
3
UniProt:Q8TAT6 NPLOC4
2
NPLOC4 [nucleoplasm]
(R-HSA-5654987)
NPLOC4 [cytosol]
(R-HSA-9755492)
0.499
5
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