Reactome | ub UBXN7 is degraded by the 26S proteasome

ub UBXN7 is degraded by the 26S proteasome

Stable Identifier

R-HSA-9755306

Type

Reaction [omitted]

Species

Homo sapiens

Compartment

cytosol

ReviewStatus

5/5

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ub UBXN7 is degraded by the 26S proteasome

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After MUL1-dependent ubiquitination, UBXN7 is degraded by the 26 S proteasome. This results in increased levels of NFE2L2 and corresponding decreased levels in HIF1alpha (Cilenti et al, 2020; Di Gregorio et al, 2021).

Literature References

PubMed ID	Title	Journal	Year
32005965	Mitochondrial MUL1 E3 ubiquitin ligase regulates Hypoxia Inducible Factor (HIF-1α) and metabolic reprogramming by modulating the UBXN7 cofactor protein Di Gregorio, J, Zervos, AS, Liao, R, Andl, T, Ambivero, CT, Cilenti, L	Sci Rep	2020
33444648	UBXN7 cofactor of CRL3^KEAP1 and CRL2^VHL ubiquitin ligase complexes mediates reciprocal regulation of NRF2 and HIF-1α proteins Di Gregorio, J, Zervos, AS, Liao, R, Andl, T, Ambivero, CT, Cilenti, L	Biochim Biophys Acta Mol Cell Res	2021