Reactome | NPLOC4 [cytosol]

NPLOC4 [cytosol]

Stable Identifier

R-HSA-9755492

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Nuclear protein localization protein 4 homolog, NPL4_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8TAT6 NPLOC4

Gene Names

NPLOC4, KIAA1499, NPL4

Chain

initiator methionine:, chain:2-608

Reference Genes

BioGPS Gene:55666 NPLOC4

COSMIC (genes):NPLOC4 NPLOC4

CTD Gene:55666 NPLOC4

dbSNP Gene:55666 NPLOC4

ENSEMBL:ENSG00000182446 NPLOC4

ENSEMBL_homo_sapiens_GENE:ENSG00000182446.15 NPLOC4

HGNC:18261 NPLOC4

KEGG Gene (Homo sapiens):55666 NPLOC4

Monarch:55666 NPLOC4

NCBI Gene:55666 NPLOC4

OMIM:606590 NPLOC4

UCSC:Q8TAT6 NPLOC4

Reference Transcript

Other Identifiers

11733893_a_at

11755047_a_at

11755406_x_at

11761364_a_at

16849882

217796_PM_s_at

217796_s_at

3774030

3774031

3774032

3774033

3774034

3774035

3774036

3774037

3774038

3774039

3774040

3774042

3774043

3774045

3774059

3774060

3774063

3774064

3774066

3774074

3774075

3774077

3774079

3774084

3774085

3774087

3774090

3774095

55666

61951_at

65788_at

8019211

90976_at

A_23_P72044

A_33_P3238966

GE55586

GO:0002376

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005783

GO:0005829

GO:0006511

GO:0006886

GO:0007030

GO:0023052

GO:0030163

GO:0030433

GO:0030970

GO:0031625

GO:0032480

GO:0034098

GO:0036435

GO:0036501

GO:0039536

GO:0042175

GO:0043130

GO:0043161

GO:0043226

GO:0044877

GO:0046872

GO:0051117

GO:0070530

GO:0098542

HMNXSV003026832

ILMN_1807600

PH_hs_0023960

TC17001954.hg

g8923608_3p_a_at

Participates

as a component of

NPLOC4:UFD1 [cytosol] (Homo sapiens)

Other forms of this molecule

NPLOC4 [nucleoplasm]

Inferred To

NPL4 [cytosol] (Saccharomyces cerevisiae)

npl4 [cytosol] (Schizosaccharomyces pombe)

npl-4.2 [cytosol] (Caenorhabditis elegans)

NPLOC4 [cytosol] (Bos taurus)

NPLOC4 [cytosol] (Canis familiaris)

NPLOC4 [cytosol] (Gallus gallus)

NPLOC4 [cytosol] (Plasmodium falciparum)

NPLOC4 [cytosol] (Sus scrofa)

Npl4 [cytosol] (Drosophila melanogaster)

Nploc4 [cytosol] (Mus musculus)

Nploc4 [cytosol] (Rattus norvegicus)

nploc4 [cytosol] (Danio rerio)

nploc4 [cytosol] (Dictyostelium discoideum)

nploc4 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

XP_011523281.1, NP_060391.2

OpenTargets

ENSG00000182446

HPA

ENSG00000182446-NPLOC4

GeneCards

Q8TAT6

Ensembl

ENST00000374747, ENSP00000331487, ENSG00000182446, ENSP00000363879, ENST00000331134

PRO

Q8TAT6

Pharos - Targets

Q8TAT6

PDB

7WWQ, 7WWP

Interactors (5)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P55072 VCP	8	Me3K315-VCP [cytosol] (R-HSA-8932209) VCP [endoplasmic reticulum membrane] (R-HSA-8943105) VCP [nucleoplasm] (R-HSA-5643745) VCP [secretory granule lumen] (R-HSA-6801039) VCP [ficolin-1-rich granule lumen] (R-HSA-6800425) VCP [extracellular region] (R-HSA-6806191) VCP [azurophil granule lumen] (R-HSA-6800438) VCP [cytosol] (R-HSA-1181251)	0.95	15
UniProt:O95786 RIGI	4	PolyUb-DDX58 [cytosol] (R-HSA-6782770) K48polyUb-DDX58 [cytosol] (R-HSA-3080568) K63polyUb-DDX58 [cytosol] (R-HSA-918191) DDX58 [cytosol] (R-HSA-168917)	0.619	6
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.59	2
UniProt:P37173 TGFBR2	9	TGFBR2 Y470D [plasma membrane] (R-HSA-3640905) TGFBR2 E526Q [plasma membrane] (R-HSA-3645770) TGFBR2 D522N [plasma membrane] (R-HSA-3640907) TGFBR2 R528H [plasma membrane] (R-HSA-3640894) TGFBR2 R528C [plasma membrane] (R-HSA-3640899) TGFBR2 K128Afs3 [cytosol] (R-HSA-3642173) TGFBR2 K128Sfs35 [cytosol] (R-HSA-3642166) NEDD8-K556,K567-TGFBR2 [plasma membrane] (R-HSA-4332222) TGFBR2 [plasma membrane] (R-HSA-170842)	0.556	3
UniProt:O94888 WIPF1	2	UBXN7 [cytosol] (R-HSA-8956071) ub-UBXN7 [cytosol] (R-HSA-9755305)	0.499	5

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