SARS-CoV-2 targets host intracellular signalling and regulatory pathways

Stable Identifier
R-HSA-9755779
Type
Pathway
Species
Homo sapiens
Related Species
Severe acute respiratory syndrome coronavirus 2
ReviewStatus
5/5
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SARS-CoV-2 targets host intracellular signalling and regulatory pathways
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Severe acute respiratory syndrome coronavirus type 2 (SARS‑CoV‑2) encodes several proteins that modulate host intracellular signaling and regulatory pathways. Among them are membrane M, nucleocapsid N and 3a proteins that directly bind to host targets associated with SARS‑CoV‑2 infection and cytokine production. This Reactome module describes several such binding events and their consequences. First, SARS‑CoV‑2 M binds to 3‑phosphoinositide‑dependent protein kinase 1 (PDPK1) to inhibit PKB/Akt activation (Ren Y et al. 2021). Second, SARS‑CoV‑1 N binds to the host 14-3-3 protein, which regulates nucleocytoplasmic shuttling and other functions of N (Tugaeva KV et al. 2021). Third, binding of viral 3a to the regulator and scaffolding protein caveolin‑1 (CAV1) may regulate virus uptake as well as the trafficking of viral structural proteins (inferred from the orthologous protein in SARS-CoV-1).
Literature References
PubMed ID Title Journal Year
33556408 The Mechanism of SARS-CoV-2 Nucleocapsid Protein Recognition by the Human 14-3-3 Proteins

Tugaeva, KV, Hawkins, DEDP, Smith, JLR, Bayfield, OW, Ker, DS, Sysoev, AA, Klychnikov, OI, Antson, AA, Sluchanko, NN

J Mol Biol 2021
34513728 SARS-CoV-2 Membrane Glycoprotein M Triggers Apoptosis With the Assistance of Nucleocapsid Protein N in Cells

Ren, Y, Wang, A, Fang, Y, Shu, T, Wu, D, Wang, C, Huang, M, Min, J, Jin, L, Zhou, W, Qiu, Y, Zhou, X

Front Cell Infect Microbiol 2021
Participants
Events
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as an event of
Disease
Name Identifier Synonyms
COVID-19 DOID:0080600 2019 Novel Coronavirus (2019-nCoV), Wuhan seafood market pneumonia virus infection, 2019-nCoV infection, Wuhan coronavirus infection
Cross References
Mondo
BioModels Database
Authored
Shamovsky, V  (2021-10-27)
Stephan, R  (2021-05-03)
Reviewed
Messina, F  (2022-02-18)
Created
Shamovsky, V  (2021-10-11)
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