Reactome | DHCR24 reduces LAN to 24,25-dhLAN

DHCR24 reduces LAN to 24,25-dhLAN

Stable Identifier

R-HSA-9755937

Type

Reaction [transition]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane, cytosol

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DHCR24 (delta(24)-sterol reductase) (review Zerenturk et al. 2013) associated with the endoplasmic reticulum membrane catalyzes the reduction of lanosterol (LAN) to 24,25-dihydrolanosterol (24,25-dhLAN) (Kandutsch & Russell 1960). Like most cholesterol synthesis enzymes, DHCR24 is transcriptionally regulated by the SREBP family of transcription factors and hence, is subject to negative regulation by cholesterol (Zerenturk et al. 2012).

Literature References

PubMed ID	Title	Journal	Year
23050906	Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation Crespo, L, Rodríguez-Acebes, S, Lasunción, MA, Daimiel, LA, Martínez-Botas, J, Gómez-Coronado, D, Fernández-Suárez, ME	Biosci Rep	2012
14404284	Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol Russell, AE, Kandutsch, AA	J. Biol. Chem.	1960