DHCR24 reduces LAN to 24,25-dhLAN

Stable Identifier
R-HSA-9755937
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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DHCR24 (delta(24)-sterol reductase) (review Zerenturk et al. 2013) associated with the endoplasmic reticulum membrane catalyzes the reduction of lanosterol (LAN) to 24,25-dihydrolanosterol (24,25-dhLAN) (Kandutsch & Russell 1960). Like most cholesterol synthesis enzymes, DHCR24 is transcriptionally regulated by the SREBP family of transcription factors and hence, is subject to negative regulation by cholesterol (Zerenturk et al. 2012).

Literature References
PubMed ID Title Journal Year
23050906 Promoter analysis of the DHCR24 (3β-hydroxysterol Δ(24)-reductase) gene: characterization of SREBP (sterol-regulatory-element-binding protein)-mediated activation

Crespo, L, Rodríguez-Acebes, S, Lasunción, MA, Daimiel, LA, Martínez-Botas, J, Gómez-Coronado, D, Fernández-Suárez, ME

Biosci Rep 2012
14404284 Preputial gland tumor sterols. 3. A metabolic pathway from lanosterol to cholesterol

Russell, AE, Kandutsch, AA

J. Biol. Chem. 1960
Participants
Participates
Catalyst Activity

delta24-sterol reductase activity of DHCR24 [endoplasmic reticulum membrane]

This event is regulated
Orthologous Events
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