PON1,3 hydrolyse ATVL to ATV

Stable Identifier
R-HSA-9756177
Type
Reaction [transition]
Species
Homo sapiens
Compartment
ReviewStatus
5/5
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Serum paraoxonase/arylesterase 1 and Serum paraoxonase/lactonase 3 (PON1 and PON3 respectively) were identified as the major enzymes involved in the hydrolysis of atorvastatin-lactone (ATVL) to atorvastatin (ATV) in human liver (Riedmaier et al. 2011). They are predominantly associated with the ER membrane (Gonzalvo et al. 1998, Riedmaier et al. 2011). It is very likely that these two enzymes also convert the corresponding hydroxyl-metabolites.
Literature References
PubMed ID Title Journal Year
9414488 Human liver paraoxonase (PON1): subcellular distribution and characterization

Villanueva, E, Pla, A, Gil, F, Rodrigo, L, Gonzalvo, MC, Hernandez, AF

J Biochem Mol Toxicol 1998
21852972 Paraoxonase (PON1 and PON3) Polymorphisms: Impact on Liver Expression and Atorvastatin-Lactone Hydrolysis

Hofmann, U, Winter, S, Klein, K, Schwab, M, Zanger, UM, Riedmaier, S

Front Pharmacol 2011
Participants
Participates
Catalyst Activity

acyl-L-homoserine-lactone lactonohydrolase activity of PON1,3:2xCa2+ dimers [endoplasmic reticulum membrane]

Orthologous Events
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