Hydroxyl radicals oxidize ST to 2,3-DHBA

Stable Identifier
R-HSA-9757462
Type
Reaction [transition]
Species
Homo sapiens
Compartment
endoplasmic reticulum lumen
ReviewStatus
5/5
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Hydroxyl radicals oxidize ST to 2,3-DHBA
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2,3-Dihydroxybenzoate (2,3-DHBA) can be formed by hydroxyl radicals attacking salicylate (ST) in animal cells (Ingelman-Sundberg et al, 1991). This result could not be confirmed in human liver microsomes using a different setup (Bojic et al, 2015)
Literature References
PubMed ID Title Journal Year
25840124 Aromatic hydroxylation of salicylic acid and aspirin by human cytochromes P450

Bojić, M, Sedgeman, CA, Nagy, LD, Guengerich, FP

Eur J Pharm Sci 2015
2064611 Hydroxylation of salicylate by microsomal fractions and cytochrome P-450. Lack of production of 2,3-dihydroxybenzoate unless hydroxyl radical formation is permitted

Ingelman-Sundberg, M, Kaur, H, Terelius, Y, Persson, JO, Halliwell, B

Biochem J 1991
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Authored
Stephan, R  (2021-08-04)
Reviewed
Huddart, R  (2021-10-13)
Created
Stephan, R  (2021-11-01)
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