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PAX3 [nucleoplasm]
Stable Identifier
R-HSA-9757859
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Paired box protein Pax-3, HuP2
Icon
Locations in the PathwayBrowser for interactor UniProt:P56693 SOX10
Expand all
Developmental Biology (Homo sapiens)
Gastrulation (Homo sapiens)
Specification of the neural plate border (Homo sapiens)
Expression of PAX3 in the neural plate border (Homo sapiens)
PAX3 [nucleoplasm] (Homo sapiens)
MITF-M-regulated melanocyte development (Homo sapiens)
Transcriptional and post-translational regulation of MITF-M expression and activity (Homo sapiens)
FOXD3 binds PAX3 (Homo sapiens)
PAX3 [nucleoplasm] (Homo sapiens)
FOXD3 gene expression (Homo sapiens)
PAX3 [nucleoplasm] (Homo sapiens)
SOX10 and PAX3 bind the MITF promoter (Homo sapiens)
PAX3 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P23760 PAX3
Gene Names
PAX3, HUP2
Chain
chain:1-479
Reference Genes
BioGPS Gene:5077 PAX3
COSMIC (genes):PAX3 PAX3
CTD Gene:5077 PAX3
dbSNP Gene:5077 PAX3
ENSEMBL:ENSG00000135903 PAX3
ENSEMBL_homo_sapiens_GENE:ENSG00000135903.20 PAX3
HGNC:8617 PAX3
KEGG Gene (Homo sapiens):5077 PAX3
Monarch:5077 PAX3
NCBI Gene:5077 PAX3
OMIM:606597 PAX3
UCSC:P23760 PAX3
Reference Transcript
RefSeq:NM_013942.4 PAX3
RefSeq:NM_181460.3 PAX3
RefSeq:NM_001127366.2 PAX3
RefSeq:NM_000438.5 PAX3
RefSeq:NM_181459.3 PAX3
RefSeq:NM_181458.3 PAX3
RefSeq:NM_181457.3 PAX3
RefSeq:NM_181461.3 PAX3
Other Identifiers
11726239_a_at
11726240_a_at
11733669_a_at
11742285_a_at
11742286_at
11755638_a_at
1344_at
1345_s_at
16908928
207679_PM_at
207679_at
207680_PM_x_at
207680_x_at
216059_PM_at
216059_at
231666_PM_at
231666_at
2600885
2600886
2600887
2600888
2600889
2600890
2600891
2600892
2600893
2600900
2600902
2600907
2600925
2600926
2600927
2600928
2600929
2600931
2600933
2600937
2600938
2600939
38900_at
45189_at
5077
61426_at
8059301
A_23_P209499
A_23_P502706
A_24_P362595
GE81842
GO:0000785
GO:0000978
GO:0000981
GO:0003677
GO:0003700
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0006351
GO:0006355
GO:0006357
GO:0006915
GO:0007399
GO:0007517
GO:0007605
GO:0009887
GO:0012501
GO:0043226
GO:0043565
GO:0045893
GO:0045944
GO:0048856
GO:0050877
GO:0071837
GO:0140110
GO:1990837
HMNXSV003037706
Hs.198.2.S1_3p_at
Hs.42146.0.A1_3p_at
ILMN_1707314
ILMN_1724061
ILMN_1757053
ILMN_2320932
PH_hs_0003095
S69369_at
S69370_s_at
TC02002811.hg
U12259_cds2_s_at
g6654637_3p_a_at
g6654637_3p_at
Participates
as a component of
FOXD3:PAX3 [nucleoplasm] (Gallus gallus)
SOX10:PAX3:MITF gene [nucleoplasm] (Homo sapiens)
PAX3:FOXD3 [nucleoplasm] (Homo sapiens)
as an input of
FOXD3 binds PAX3 (Gallus gallus)
FOXD3 binds PAX3 (Homo sapiens)
SOX10 and PAX3 bind the MITF promoter (Homo sapiens)
as an output of
Expression of PAX3 in the neural plate border (Homo sapiens)
This entity regulates
Positively
FOXD3 gene expression
(Homo sapiens)
Other forms of this molecule
PAX3 (1-319) [nucleoplasm]
Cross References
RefSeq
NP_852126.1
,
NP_852122.1
,
NP_852124.1
,
NP_039230.1
,
NP_852125.1
,
NP_000429.2
,
NP_001120838.1
,
NP_852123.1
OpenTargets
ENSG00000135903
HPA
ENSG00000135903-PAX3
GeneCards
P23760
Ensembl
ENSP00000386817
,
ENSP00000375922
,
ENST00000258387
,
ENST00000409828
,
ENSP00000258387
,
ENSP00000342092
,
ENST00000344493
,
ENSG00000135903
,
ENSP00000386750
,
ENST00000392069
,
ENST00000336840
,
ENST00000409551
,
ENST00000392070
,
ENSP00000375921
,
ENSP00000338767
,
ENSP00000343052
,
ENST00000350526
PRO
P23760
Pharos - Targets
P23760
Orphanet
16611
PDB
3CMY
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P20265 POU3F2
1
POU3F2 [nucleoplasm]
(R-HSA-9613754)
0.527
2
UniProt:P50222 MEOX2
0.527
2
UniProt:Q99435 NELL2
1
NELL2 [extracellular region]
(R-HSA-9010198)
0.527
2
UniProt:Q9Y657 SPIN1
0.527
2
UniProt:P56693 SOX10
2
SOX10 [nucleoplasm]
(R-HSA-9613639)
p-T240,T244-SOX10 [nucleoplasm]
(R-HSA-9824578)
0.527
2
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