Reactome | MAN2A2 [Golgi membrane]

MAN2A2 [Golgi membrane]

Stable Identifier

R-HSA-975824

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Alpha-mannosidase 2x, MA2A2_HUMAN

Locations in the PathwayBrowser

Expand all

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        Reactions specific to the complex N-glycan synthesis pathway (Homo sapiens)
        
        Trimming of mannoses on the alpha1,6 arm by MAN2A1 (Homo sapiens)
        
        MAN2:Zn2+ [Golgi membrane] (Homo sapiens)
        
        MAN2A2:Zn2+ [Golgi membrane] (Homo sapiens)
        
        MAN2A2 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:P49641 MAN2A2

Gene Names

MAN2A2, MANA2X

Chain

chain:1-1150

Reference Genes

BioGPS Gene:4122 MAN2A2

COSMIC (genes):MAN2A2 MAN2A2

CTD Gene:4122 MAN2A2

dbSNP Gene:4122 MAN2A2

ENSEMBL:ENSG00000196547 MAN2A2

ENSEMBL_homo_sapiens_GENE:ENSG00000196547.15 MAN2A2

HGNC:6825 MAN2A2

KEGG Gene (Homo sapiens):4122 MAN2A2

Monarch:4122 MAN2A2

NCBI Gene:4122 MAN2A2

OMIM:600988 MAN2A2

UCSC:P49641 MAN2A2

Reference Transcript

Other Identifiers

11717532_at

11717533_at

11751264_a_at

11763769_a_at

16804995

202032_PM_s_at

202032_s_at

219999_PM_at

219999_at

3608471

3608473

3608474

3608475

3608477

3608478

3608479

3608480

3608481

3608482

3608485

3608487

3608488

3608489

3608490

3608492

3608493

3608494

3608497

3608498

3608499

3608500

3608502

3608505

3608510

3608511

3608512

3608515

3608516

3608517

3608518

3608519

38188_s_at

3874226

4122

41766_at

67217_at

7986132

89830_at

A_14_P129731

A_23_P37569

A_24_P381838

A_33_P3316403

GE81599

GE82426

GE88063

GO:0000139

GO:0003824

GO:0004559

GO:0004572

GO:0005794

GO:0005975

GO:0006013

GO:0006486

GO:0006491

GO:0008152

GO:0015923

GO:0016020

GO:0016787

GO:0016798

GO:0016799

GO:0030246

GO:0036211

GO:0043226

GO:0046872

GO:1901135

HMNXSV003001000

HMNXSV003044331

ILMN_1815148

L28821_at

PH_hs_0022317

PH_hs_0026783

PH_hs_0031558

TC15000872.hg

g5540099_3p_a_at

g8924129_3p_at

Participates

as a candidate of

intra-Golgi cargo [Golgi membrane] (Homo sapiens)

as a component of

MAN2A2:Zn2+ [Golgi membrane] (Homo sapiens)

Other forms of this molecule

MAN2A2 [transport vesicle]

Inferred To

MAN2A2 [Golgi membrane] (Bos taurus)

MAN2A2 [Golgi membrane] (Canis familiaris)

MAN2A2 [Golgi membrane] (Drosophila melanogaster)

MAN2A2 [Golgi membrane] (Gallus gallus)

MAN2A2 [Golgi membrane] (Mus musculus)

MAN2A2 [Golgi membrane] (Sus scrofa)

Ghost homologue of MAN2A2 [Golgi membrane] (Xenopus tropicalis)

Man2a2 [Golgi membrane] (Rattus norvegicus)

aman-2 [Golgi membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_016877674.1, NP_006113.2

OpenTargets

ENSG00000196547

HPA

ENSG00000196547-MAN2A2

GeneCards

P49641

Ensembl

ENSG00000196547, ENSP00000353655, ENST00000360468, ENSP00000452948, ENST00000559717

PRO

P49641

Pharos - Targets

P49641

HMDB Protein

HMDBP11809