Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex

Stable Identifier
R-HSA-975861
Type
Reaction [transition]
Species
Homo sapiens
Related Species
Escherichia coli
Compartment
plasma membrane, cytosol
ReviewStatus
5/5
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Phosphorylation of IRAK2 bound to the activated IRAK4:MyD88 oligomerl:activated TLR5 or 10 complex
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IRAK4 deficient macrophages fail to induce IRAK2 phosphorylation (Kawagoe et al. 2008), suggesting that activated IRAK4 phosphorylates IRAK2 as it does IRAK1.

Phosphorylation sites of IRAK2 remain to be characterized.

Literature References
PubMed ID Title Journal Year
18438411 Sequential control of Toll-like receptor-dependent responses by IRAK1 and IRAK2

Kumagai, Y, Kawai, T, Takeuchi, O, Saitoh, T, Matsushita, K, Sato, S, Akira, S, Matsui, K, Kato, H, Kawagoe, T

Nat Immunol 2008
Participants
Input
Output
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane]

Physical Entity
IRAK2:p-S,2T-IRAK4:oligo-MyD88:activated TLR5/10 [plasma membrane] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Activated IRAK4 bound to activated TLR : MyD88 complex phosphorylates IRAK2 (Gallus gallus)
Authored
Shamovsky, V  (2010-10-06)
Reviewed
Li, L  (2011-08-04)
Gillespie, ME  (2011-02-10)
Created
Shamovsky, V  (2010-10-06)
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