Transport of RCbl within the body

Stable Identifier
R-HSA-9758890
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
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The steps of transport of cobalamins (RCbl) from the enterocyte to the cells in which it will function as a cofactor, together with its reuptake in the renal tubule, are annotated here. While methylcobalamin is the predominant cobalamin in the blood (Chu et al. 1993), other cobalamins including cyanocobalamin and adenosylcobalamin are also present and the proteins involved in these processes accommodate all of them (Banerjee et al. 2021; Nielsen et al. 2012; Quadros 2010). This broad specificity is indicated by annotating R-cob(III)alamin (RCbl - CHEBI:140785) as the cargo in all of these processes.
Literature References
PubMed ID Title Journal Year
19832808 Advances in the understanding of cobalamin assimilation and metabolism

Quadros, EV

Br. J. Haematol. 2010
33797888 Redox-Linked Coordination Chemistry Directs Vitamin B12 Trafficking

Gouda, H, Pillay, S, Banerjee, R

Acc Chem Res 2021
22547309 Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway

Rasmussen, MR, Moestrup, SK, Andersen, CB, Nielsen, MJ, Nexø, E

Nat Rev Gastroenterol Hepatol 2012
8487649 The methylcobalamin metabolism of cultured human fibroblasts

Colligan, PD, Begley, JA, Chu, RC, Hall, CA

Metabolism 1993
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