Reactome | Transport of RCbl within the body

Transport of RCbl within the body

Stable Identifier

R-HSA-9758890

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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The steps of transport of cobalamins (RCbl) from the enterocyte to the cells in which it will function as a cofactor, together with its reuptake in the renal tubule, are annotated here. While methylcobalamin is the predominant cobalamin in the blood (Chu et al. 1993), other cobalamins including cyanocobalamin and adenosylcobalamin are also present and the proteins involved in these processes accommodate all of them (Banerjee et al. 2021; Nielsen et al. 2012; Quadros 2010). This broad specificity is indicated by annotating R-cob(III)alamin (RCbl - CHEBI:140785) as the cargo in all of these processes.

Literature References

PubMed ID	Title	Journal	Year
19832808	Advances in the understanding of cobalamin assimilation and metabolism Quadros, EV	Br. J. Haematol.	2010
33797888	Redox-Linked Coordination Chemistry Directs Vitamin B₁₂ Trafficking Gouda, H, Pillay, S, Banerjee, R	Acc Chem Res	2021
22547309	Vitamin B12 transport from food to the body's cells--a sophisticated, multistep pathway Rasmussen, MR, Moestrup, SK, Andersen, CB, Nielsen, MJ, Nexø, E	Nat Rev Gastroenterol Hepatol	2012
8487649	The methylcobalamin metabolism of cultured human fibroblasts Colligan, PD, Begley, JA, Chu, RC, Hall, CA	Metabolism	1993