Reactome | MGAT5 [Golgi membrane]

MGAT5 [Golgi membrane]

Stable Identifier

R-HSA-975896

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

Golgi membrane

Synonyms

Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A, MGT5A_HUMAN

Locations in the PathwayBrowser for interactor UniProt:P51674 GPM6A

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - SARS-CoV Infections (Homo sapiens)
      - SARS-CoV-2 Infection (Homo sapiens)
        
        Late SARS-CoV-2 Infection Events (Homo sapiens)
        
        Translation of Structural Proteins (Homo sapiens)
        
        Maturation of spike protein (Homo sapiens)
        
        Spike trimer glycoside chains get additional branches (Homo sapiens)
        
        MGAT5 [Golgi membrane] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        N-Glycan antennae elongation (Homo sapiens)
        
        Addition of GlcNAc to position 5 by MGAT5 (Homo sapiens)
        
        MGAT5 [Golgi membrane] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q09328 MGAT5

Gene Names

MGAT5, GGNT5

Chain

chain:1-741, chain:31-741

Reference Genes

BioGPS Gene:4249 MGAT5

COSMIC (genes):MGAT5 MGAT5

CTD Gene:4249 MGAT5

dbSNP Gene:4249 MGAT5

ENSEMBL:ENSG00000152127 MGAT5

HGNC:7049 MGAT5

KEGG:hsa:4249 MGAT5

Monarch:4249 MGAT5

NCBI Gene:4249 MGAT5

OMIM:601774 MGAT5

UCSC:Q09328 MGAT5

Reference Transcript

Other Identifiers

11738064_at

16885874

206720_PM_at

206720_at

212098_PM_at

212098_at

2506904

2506951

2506953

2506954

2506955

2506956

2506957

2506964

2506980

2506982

2506986

2506987

2506988

2506989

2506991

2506992

2507000

2507021

2507027

2507028

2507030

2507044

2507048

2507049

2507050

2507051

2507052

2507053

2507054

2507055

2507056

2507057

2507058

2507082

31313_at

34866_at

4249

72015_at

8045349

A_14_P107154

A_14_P128964

A_14_P136465

A_23_P16743

A_24_P915784

A_33_P3255209

D17716_at

GE54519

GE58288

GO:0000139

GO:0003824

GO:0004864

GO:0005576

GO:0005794

GO:0006486

GO:0006487

GO:0008375

GO:0016020

GO:0016740

GO:0016757

GO:0018279

GO:0019082

GO:0030144

GO:0030145

GO:0030335

GO:0043226

GO:0070062

GO:0098772

GO:0140096

GO:1903614

GO:1904894

HMNXSV003036362

Hs.4988.0.S1_3p_at

ILMN_1731049

PH_hs_0000507

PH_hs_0024581

S80050_at

TC02000874.hg

TC02003597.hg

X91653_s_at

g6031185_3p_at

Inferred To

mgat5 [Golgi membrane] (Danio rerio)

mgat5 [Golgi membrane] (Xenopus tropicalis)

MGAT5 [Golgi membrane] (Bos taurus)

MGAT5 [Golgi membrane] (Canis familiaris)

MGAT5 [Golgi membrane] (Gallus gallus)

MGAT5 [Golgi membrane] (Mus musculus)

MGAT5 [Golgi membrane] (Rattus norvegicus)

MGAT5 [Golgi membrane] (Sus scrofa)

gly-2 [Golgi membrane] (Caenorhabditis elegans)

Cross References

RefSeq

XP_005263726.1, XP_011509503.1, XP_016859636.1, XP_016859637.1, XP_011509504.1, XP_006712597.1, NP_002401.1, XP_011509501.1, XP_005263725.1, XP_005263727.1, XP_011509502.1

OpenTargets

ENSG00000152127

ENSEMBL

ENST00000281923, ENSP00000386377, ENST00000409645, ENSP00000281923

HPA

ENSG00000152127-MGAT5

ZINC target

Q09328

PRO

Q09328

Pharos - Targets

Q09328

GlyGen

Q09328

PDB

6YJT, 6YJS, 7YYI, 6YJQ, 6YJR, 7Z08, 7Z07, 5ZIB, 5ZIC, 6YJV, 6YJU, 8CE3, 7Z0B

HMDB Protein

HMDBP01705

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13747 HLA-E	7	HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (R-HSA-197643) HLA class I histocompatibility antigen, E alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983090) HLA class I histocompatibility antigen, E alpha chain precursor [Golgi membrane] (R-HSA-983339) HLA class I histocompatibility antigen, E alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983407) HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane] (R-HSA-1236744) HLA class I histocompatibility antigen, E alpha chain precursor [recycling endosome membrane] (R-HSA-8863974) HLA class I histocompatibility antigen, E alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236793)	0.527	2
UniProt:Q9GZY8 MFF			0.527	2
UniProt:P01848 TRAC	1	TRAC [plasma membrane] (R-HSA-198175)	0.527	2
UniProt:P51674 GPM6A			0.527	2
UniProt:Q03405 PLAUR	7	PLAUR [endoplasmic reticulum membrane] (R-HSA-162703) GPI-PLAUR [endoplasmic reticulum membrane] (R-HSA-162687) PLAUR(306-335) [endoplasmic reticulum lumen] (R-HSA-162707) PLAUR(23-335) [endoplasmic reticulum membrane] (R-HSA-162866) GPI-PLAUR [plasma membrane] (R-HSA-158946) PLAUR [plasma membrane] (R-HSA-6806165) GPI-PLAUR [specific granule membrane] (R-HSA-6806143)	0.527	2
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.527	2

Cite Us!