N-acetylglucosaminyltransferase (GnT)-IV catalyzes the addition of GlcNAc beta,1,4 on the GlcNAc beta1,2 Man,alpha1,3 arm of both complex and hybrid N-glycans (Oguri S et al, 2006). Two human GnT-IV isozymes have been characterized (MGAT4A, MGAT4B) , plus a putative MGAT4C on chromosome 2 (Furukawa T et al, 1999). Aberrant expression of MGAT4A or MGAT4B is associated with pancreatic cancer (Ide Y et al, 2006; Kudo T et al , 2007)
Hayashi, Y, Hoshi, M, Fukushige, S, Horii, A, Yokoyama, T, Inoue, H, Yatsuoka, T, Makino, N, Furukawa, T, Sunamura, M, Youssef, EM
Deguchi, K, Nakagawa, T, Nakagawa, H, Kudo, T, Hamaguchi, J, Nishimura, S, Nakanishi, K, Kamiyama, N, Yokoo, H, Takahashi, M, Todo, S, Kamiyama, T
Nakagawa, T, Tanemura, M, Kozutsumi, Y, Miyoshi, E, Gu, J, Nishida, T, Yamamoto, H, Taniguchi, N, Ide, Y, Ito, T
Oguri, S, Minowa, MT, Takeuchi, M, Yoshida, A
alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity of MGAT4s [Golgi membrane]
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