Reactome | K7 ub-SQSTM1 [cytosol]

K7 ub-SQSTM1 [cytosol]

Stable Identifier

R-HSA-9759088

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

p62, Sequestosome-1, SQSTM_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13501 SQSTM1

Gene Names

SQSTM1, ORCA, OSIL

Chain

initiator methionine:, chain:2-440, initiator methionine:

Reference Genes

BioGPS Gene:8878 SQSTM1

COSMIC (genes):SQSTM1 SQSTM1

CTD Gene:8878 SQSTM1

dbSNP Gene:8878 SQSTM1

ENSEMBL:ENSG00000161011 SQSTM1

ENSEMBL_homo_sapiens_GENE:ENSG00000161011.20 SQSTM1

ENSEMBL_homo_sapiens_GENE:ENSG00000284099.3 SQSTM1

HGNC:11280 SQSTM1

KEGG Gene (Homo sapiens):8878 SQSTM1

Monarch:8878 SQSTM1

NCBI Gene:8878 SQSTM1

OMIM:601530 SQSTM1

UCSC:Q13501 SQSTM1

Reference Transcript

Other Identifiers

11717290_s_at

11727031_a_at

11745754_x_at

11752843_x_at

11756761_x_at

16993458

201471_PM_s_at

201471_s_at

213112_PM_s_at

213112_s_at

2844499

2844500

2844505

2844506

2844507

2844508

2844509

2844512

2844513

2844514

2844515

2844516

2844518

2844523

2844524

2844528

2844529

2844535

2844536

2844537

2844538

2844539

2844540

2844541

2844542

40898_at

8110569

8878

A_14_P109999

A_23_P81399

GE79794

GO:0000122

GO:0000407

GO:0000422

GO:0000423

GO:0000425

GO:0000932

GO:0001659

GO:0001934

GO:0002376

GO:0002931

GO:0005080

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005764

GO:0005768

GO:0005770

GO:0005773

GO:0005776

GO:0005783

GO:0005829

GO:0005929

GO:0006351

GO:0006355

GO:0006366

GO:0006511

GO:0006606

GO:0006886

GO:0006913

GO:0006914

GO:0006915

GO:0007005

GO:0007032

GO:0008104

GO:0008270

GO:0010508

GO:0010821

GO:0012501

GO:0016192

GO:0016197

GO:0016234

GO:0016235

GO:0016236

GO:0016605

GO:0019899

GO:0019901

GO:0023052

GO:0030017

GO:0030154

GO:0030163

GO:0030674

GO:0030971

GO:0031397

GO:0031410

GO:0031625

GO:0034144

GO:0035255

GO:0035556

GO:0035591

GO:0035973

GO:0036211

GO:0038023

GO:0042169

GO:0042802

GO:0043065

GO:0043122

GO:0043130

GO:0043226

GO:0043231

GO:0043232

GO:0044753

GO:0044754

GO:0044877

GO:0045944

GO:0046578

GO:0046872

GO:0060089

GO:0060090

GO:0061635

GO:0070062

GO:0070342

GO:0070530

GO:0071211

GO:0072659

GO:0097009

GO:0097225

GO:0097413

GO:0098542

GO:0098780

GO:0140036

GO:0140311

GO:0140313

GO:0140693

GO:0140694

GO:1900273

GO:1903078

GO:1905719

HMNXSV003033729

Hs.279891.1.A1_3p_at

ILMN_1662618

PH_hs_0010763

U46751_at

g4505570_3p_s_at

Participates

as an output of

TRIM21 ubiquitinates SQSTM1 (Homo sapiens)

This entity regulates

Negatively

SQSTM1 oligomerizes (Homo sapiens)

Other forms of this molecule

SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol]

SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol]

p-S349 SQSTM1 [cytosol]

ub K420 p-S349 SQSTM1 [cytosol]

SQSTM1 [nucleoplasm]

SQSTM1 [cytosol]

Inferred To

SQSTM1 [cytosol] (Bos taurus)

SQSTM1 [cytosol] (Canis familiaris)

SQSTM1 [cytosol] (Gallus gallus)

SQSTM1 [cytosol] (Sus scrofa)

gldi-4 [cytosol] (Caenorhabditis elegans)

sqstm1 [cytosol] (Danio rerio)

sqstm1 [cytosol] (Xenopus tropicalis)

K7 ub-SQSTM1 [cytosol] (Dictyostelium discoideum)

K7 ub-SQSTM1 [cytosol] (Drosophila melanogaster)

K7 ub-SQSTM1 [cytosol] (Mus musculus)

K7 ub-SQSTM1 [cytosol] (Rattus norvegicus)

Modified Residues

Name

ubiquitinylated lysine (K63_polyubiquitin chain [cytosol]) at 7

Coordinate

Modification

K63_polyubiquitin chain [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_003891.1, NP_001135771.1, NP_001135770.1, XP_016865499.1

Guide to Pharmacology - Targets

3213

OpenTargets

ENSG00000161011

HPA

ENSG00000161011-SQSTM1

GeneCards

Q13501

Ensembl

ENSP00000495843, ENST00000360718, ENST00000640444, ENSP00000353944, ENSG00000161011, ENST00000389805, ENSP00000374455, ENSP00000491834, ENSG00000284099, ENST00000643389

PRO

Q13501

Pharos - Targets

Q13501

Orphanet

20429

PDB

5YP7, 2JY8, 5YPB, 5YPG, 6TGY, 5YPC, 5YPH, 5YP8, 6KHZ, 6MJ7, 2JY7, 7R1O, 5YPE, 6JM4, 4UF8, 5YPF, 5YPA, 4MJS, 4UF9, 2K0B, 6TH3, 2KNV, 1Q02

Interactors (59)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9GZQ8 MAP1LC3B	3	MAP1LC3B [autophagosome membrane] (R-HSA-5683641) MAP1LC3B(2-121) [cytosol] (R-HSA-5682674) MAP1LC3B [cytosol] (R-HSA-5205651)	0.978	31
UniProt:P60520 GABARAPL2	3	GABARAPL2 [autophagosome membrane] (R-HSA-5683633) GABARAPL2(1-117) [cytosol] (R-HSA-5682641) GABARAPL2 [cytosol] (R-HSA-5671758)	0.97	25
UniProt:Q14145 KEAP1	3	Ub-KEAP1 [cytosol] (R-HSA-6782766) ub-KEAP1 [cytosol] (R-HSA-9766647) KEAP1 [cytosol] (R-HSA-976038)	0.967	21
UniProt:Q9H0R8 GABARAPL1	3	GABARAPL1 [autophagosome membrane] (R-HSA-5683637) GABARAPL1(1-117) [cytosol] (R-HSA-5682659) GABARAPL1 [cytosol] (R-HSA-5671757)	0.953	18
UniProt:Q9H492 MAP1LC3A	3	MAP1LC3A [autophagosome membrane] (R-HSA-5683640) MAP1LC3A(1-121) [cytosol] (R-HSA-5682681) MAP1LC3A [cytosol] (R-HSA-5205676)	0.951	16
UniProt:O95166 GABARAP	3	GABARAP [autophagosome membrane] (R-HSA-5683634) GABARAP(1-117) [cytosol] (R-HSA-5682696) GABARAP [cytosol] (R-HSA-975521)	0.948	17
UniProt:Q9BXW4 MAP1LC3C	3	MAP1LC3C [autophagosome membrane] (R-HSA-5683638) MAP1LC3C(1-147) [cytosol] (R-HSA-5682653) MAP1LC3C [cytosol] (R-HSA-5679223)	0.901	8
UniProt:P41743 PRKCI	3	PRKCI [nucleoplasm] (R-HSA-9021345) PRKCI [cytosol] (R-HSA-58206) PRKCI [plasma membrane] (R-HSA-420005)	0.894	11
UniProt:Q13501 SQSTM1	7	SQSTM1(2-251)-p-7Y-ALK(1058-1620) fusion [cytosol] (R-HSA-9711967) SQSTM1(2-251)-ALK(1058-1620) fusion [cytosol] (R-HSA-9711954) K7 ub-SQSTM1 [cytosol] (R-HSA-9759088) p-S349 SQSTM1 [cytosol] (R-HSA-9766524) ub K420 p-S349 SQSTM1 [cytosol] (R-HSA-9766536) SQSTM1 [nucleoplasm] (R-HSA-210961) SQSTM1 [cytosol] (R-HSA-193937)	0.888	10
IntAct:EBI-4399559 UBIQ			0.829	6
UniProt:P0CG48 UBC	20	UBC(381-456) [endocytic vesicle membrane] (R-HSA-939218) UBC(533-608) [endocytic vesicle membrane] (R-HSA-939220) UBC(609-684) [endocytic vesicle membrane] (R-HSA-939223) UBC(457-532) [endocytic vesicle membrane] (R-HSA-939195) UBC(153-228) [endocytic vesicle membrane] (R-HSA-939194) UBC(305-380) [endocytic vesicle membrane] (R-HSA-939228) UBC(229-304) [endocytic vesicle membrane] (R-HSA-939177) UBC(77-152) [endocytic vesicle membrane] (R-HSA-939210) UBC(1-76) [endocytic vesicle membrane] (R-HSA-939245) Ub-565-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783166) Ub-337-UBC(305-380) [mitochondrial outer membrane] (R-HSA-6783121) Ub-185-UBC(153-228) [mitochondrial outer membrane] (R-HSA-6783154) Ub-261-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783028) Ub-413-UBC(381-456) [mitochondrial outer membrane] (R-HSA-6783061) Ub-109-UBC(77-152) [mitochondrial outer membrane] (R-HSA-6783158) Ub-641-UBC(609-684) [mitochondrial outer membrane] (R-HSA-6783182) Ub-33-UBC(1-76) [mitochondrial outer membrane] (R-HSA-6783073) Ub-489-UBC(457-532) [mitochondrial outer membrane] (R-HSA-6783078) Ub-291-UBC(229-304) [mitochondrial outer membrane] (R-HSA-6783193) Ub-595-UBC(533-608) [mitochondrial outer membrane] (R-HSA-6783130)	0.806	5
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.801	8
UniProt:Q14596 NBR1	2	NBR1 [peroxisomal membrane] (R-HSA-9665177) NBR1 [cytosol] (R-HSA-9665180)	0.775	7
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.771	11
UniProt:P58004 SESN2	1	SESN2 [cytosol] (R-HSA-5629143)	0.728	9
UniProt:Q05513 PRKCZ	5	p-T410,T563-PRKCZ [cytosol] (R-HSA-5218698) PRKCZ [cytosol] (R-HSA-58218) PRKCZ [cell junction] (R-HSA-2134483) p-T410-PRKCZ [cytosol] (R-HSA-437181) pS, p-T410-PRKCZ [cytosol] (R-HSA-9632824)	0.725	6
UniProt:Q8IZQ1 WDFY3			0.709	7
UniProt:Q9Y4K3 TRAF6	8	K48polyUb-TRAF6 [cytosol] (R-HSA-6783233) PolyUb-TRAF6 [cytosol] (R-HSA-6782845) TRAF6 [endosome membrane] (R-HSA-450272) K63polyUb-TRAF6 [endosome membrane] (R-HSA-450227) TRAF6 [cytosol] (R-HSA-166366) K63polyUb-TRAF6 [cytosol] (R-HSA-2685681) K63polyUb-TRAF6 [plasma membrane] (R-HSA-936980) TRAF6 [plasma membrane] (R-HSA-936955)	0.688	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.67	18
UniProt:Q15038 DAZP2			0.666	4
UniProt:P54253 ATX1			0.666	4
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.666	4
UniProt:Q13163 MAP2K5	1	MAP2K5 [cytosol] (R-HSA-198722)	0.666	5
UniProt:Q9BPW8 NIPS1			0.65	3
UniProt:P54725 RAD23A	1	RAD23A [nucleoplasm] (R-HSA-5688076)	0.635	3
UniProt:P11473 VDR	2	polySUMO2-VDR [nucleoplasm] (R-HSA-4546376) VDR [nucleoplasm] (R-HSA-375512)	0.591	4
UniProt:Q6IRU7	1	Cep78 [cytosol] (R-MMU-380304)	0.564	2
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.558	7
UniProt:Q9UGJ0 PRKAG2	2	PRKAG2 [nucleoplasm] (R-HSA-164130) PRKAG2 [cytosol] (R-HSA-200419)	0.556	3
UniProt:O14682 ENC1			0.556	7
UniProt:O14576-2 O145762			0.556	3
UniProt:Q9UBQ0-2 VPS29			0.556	3
UniProt:P34972 CNR2	1	CNR2 [plasma membrane] (R-HSA-419372)	0.556	5
UniProt:P19544-6 WT1			0.556	3
UniProt:P12709	4	GPI [secretory granule lumen] (R-SCE-6801495) GPI [extracellular region] (R-SCE-6806478) GPI [ficolin-1-rich granule lumen] (R-SCE-6801506) GPI [cytosol] (R-SCE-70468)	0.556	3
UniProt:A8K2U6 A8K2U6			0.556	3
IntAct:EBI-25830852 RZPDO839G03145			0.556	3
UniProt:P17028 ZNF24			0.556	3
UniProt:Q9UNE7 STUB1	1	STUB1 [cytosol] (R-HSA-975970)	0.556	3
UniProt:P0DMV8 HSPA1A	4	HSPA1A [nucleoplasm] (R-HSA-6792605) HSPA1A [extracellular region] (R-HSA-6805872) HSPA1A [ficolin-1-rich granule lumen] (R-HSA-6801496) HSPA1A [cytosol] (R-HSA-6792602)	0.556	3
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	6
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:Q2V2M9 FHOD3			0.543	6
UniProt:Q2V2M9-4 FHOD3			0.543	4
UniProt:P84022 SMAD3	20	Ub-SMAD3 [cytosol] (R-HSA-6782830) p-S423,S425-SMAD3 D258N [cytosol] (R-HSA-3315470) p-S423,S425-SMAD3 R268C [cytosol] (R-HSA-3315075) p-S423,S425-SMAD3 R268H [cytosol] (R-HSA-3315080) SMAD3 Q316* [cytosol] (R-HSA-9668765) SMAD3 Y384* [cytosol] (R-HSA-9668782) SMAD3 W326* [cytosol] (R-HSA-9668766) SMAD3 E246* [cytosol] (R-HSA-9668776) SMAD3 Q358* [cytosol] (R-HSA-9668772) SMAD3 Q322* [cytosol] (R-HSA-9668773) SMAD3 S425F [cytosol] (R-HSA-8944158) SMAD3 E383* [cytosol] (R-HSA-9668775) SMAD3 R368* [cytosol] (R-HSA-9668768) SMAD3 Y298* [cytosol] (R-HSA-9668769) SMAD3 S425C [cytosol] (R-HSA-3308499) p-S208-SMAD3 [cytosol] (R-HSA-9731114) SMAD3 [nucleoplasm] (R-HSA-206150) 2xADPRib-p-S423,S425-SMAD3 [nucleoplasm] (R-HSA-2187326) Ub,p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-9773841) p-T179,S423,S425-SMAD3 [nucleoplasm] (R-HSA-2176471)	0.543	3
UniProt:O95817 BAG3	1	BAG3 [cytosol] (R-HSA-5255451)	0.537	3
UniProt:P57739 CLDN2	2	CLDN2 [plasma membrane] (R-HSA-419994) CLDN2 [cell junction] (R-HSA-421235)	0.537	4
UniProt:Q15334 L2GL1			0.527	2
UniProt:O15530 PDPK1	3	p-S241-PDPK1 [cytosol] (R-HSA-9860799) PDPK1 [cytosol] (R-HSA-202210) PDPK1 [plasma membrane] (R-HSA-61459)	0.527	3
UniProt:P16070 CD44	2	CD44 [secretory granule membrane] (R-HSA-6804776) CD44 [plasma membrane] (R-HSA-1031688)	0.527	2
UniProt:Q9Y6K9 IKBKG	12	IKBKG D406V [cytosol] (R-HSA-5262943) IKBKG L153R [cytosol] (R-HSA-5262879) IKBKG E391* [cytosol] (R-HSA-5262924) IKBKG C417R [cytosol] (R-HSA-5262858) IKBKG R173G [cytosol] (R-HSA-5262966) IKBKG R175P [cytosol] (R-HSA-5262916) IKBKG 420Wext447 [cytosol] (R-HSA-5262978) monoSUMO1-K277,K309-IKBKG [nucleoplasm] (R-HSA-4755449) IKBKG [nucleoplasm] (R-HSA-4755413) K63polyUb-IKBKG [cytosol] (R-HSA-202530) Ub-285-IKBKG [cytosol] (R-HSA-741397) IKBKG [cytosol] (R-HSA-168108)	0.524	2
UniProt:Q96B97 SH3KBP1	3	SH3KBP1 [plasma membrane] (R-HSA-182955) SH3KBP1 [cytosol] (R-HSA-182957) Ub-SH3KBP1 [cytosol] (R-HSA-182926)	0.524	4
UniProt:Q9UDY8 MALT1	1	MALT1 [cytosol] (R-HSA-202461)	0.524	2
UniProt:P38182	12	ATG8 [cytosol] (R-SCE-5205651) ATG8 [cytosol] (R-SCE-5205676) ATG8 [cytosol] (R-SCE-975521) ATG8 [cytosol] (R-SCE-5679223) ATG8 [cytosol] (R-SCE-5682696) ATG8 [cytosol] (R-SCE-5682674) ATG8 [cytosol] (R-SCE-5682653) ATG8 [cytosol] (R-SCE-5682681) ATG8 [autophagosome membrane] (R-SCE-5683634) ATG8 [autophagosome membrane] (R-SCE-5683638) ATG8 [autophagosome membrane] (R-SCE-5683640) ATG8 [autophagosome membrane] (R-SCE-5683641)	0.508	3
UniProt:P12504 VIF			0.499	2
UniProt:P04629 NTRK1	4	p-5Y-NTRK1 [Golgi membrane] (R-HSA-3008810) NTRK1 [Golgi membrane] (R-HSA-3008805) NTRK1 [plasma membrane] (R-HSA-3008784) p-5Y-NTRK1 [plasma membrane] (R-HSA-3009413)	0.499	2
UniProt:O70405	7	ULK1 [recycling endosome] (R-MMU-8854761) phospho-p-S758-ULK1 [cytosol] (R-MMU-5672131) phospho-p-S317,467,556,638,T575-ULK1 [cytosol] (R-MMU-5673747) phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [cytosol] (R-MMU-5675858) phospho-p-T180,S317,S467,S556,S638,T575-ULK1 [endoplasmic reticulum membrane] (R-MMU-8948047) ULK1 [mitochondrial outer membrane] (R-MMU-8948145) ULK1 [cytosol] (R-MMU-1632847)	0.499	2
UniProt:Q9NX00 TM160			0.483	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	14

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