Reactome | Addition of GlcNAc to position 5 by MGAT5

Addition of GlcNAc to position 5 by MGAT5

Stable Identifier

R-HSA-975916

Type

Reaction [transition]

Species

Homo sapiens

Compartment

Golgi membrane, Golgi lumen

ReviewStatus

5/5

Locations in the PathwayBrowser

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Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Asparagine N-linked glycosylation (Homo sapiens)
    - Transport to the Golgi and subsequent modification (Homo sapiens)
      - N-glycan antennae elongation in the medial/trans-Golgi (Homo sapiens)
        
        N-Glycan antennae elongation (Homo sapiens)
        
        Addition of GlcNAc to position 5 by MGAT5 (Homo sapiens)

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Addition of GlcNAc to position 5 by MGAT5

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N-acetylglucosaminyltransferase (GnT)-V catalyzes the addition of GlcNAc beta 1,4 on the GlcNAc beta1,2 Man,alpha1,6 arm of complex type N-Glycans (Park C et al, 1999; Granowski M et al, 2000; Wang L et al, 2007). The activity of MGAT5 competes with MGAT3 (Pinho SS et al, 2009) and is associated with gastric cancer (Tian H et al, 2008) and multiple sclerosis (Brynedal B et al, 2010).

Literature References

PubMed ID	Title	Journal	Year
18931531	The implication of N-acetylglucosaminyltransferase V expression in gastric cancer Tsujimoto, M, Miyoshi, E, Matsuura, N, Taniguchi, N, Ito, Y, Shaker, M, Kawaguchi, N, Tian, H	Pathobiology	2008
19403558	The role of N-acetylglucosaminyltransferase III and V in the post-transcriptional modifications of E-cadherin Magalhães, AM, Figueiredo, J, Carneiro, F, Xiaogang, W, Ferreira, AC, Gärtner, F, Reis, CA, Seruca, R, Paredes, J, Pinho, SS	Hum Mol Genet	2009
10700233	Suppression of tumor growth and metastasis in Mgat5-deficient mice Muller, WJ, Khokha, R, Granovsky, M, Dennis, JW, Pawling, J, Fata, J	Nat Med	2000
20117844	MGAT5 alters the severity of multiple sclerosis Martinelli-Boneschi, F, Brynedal, B, Edan, G, Comi, G, Wojcik, J, Hillert, J, Yaouanq, J, Debailleul, V, Esposito, F, Abderrahim, H	J Neuroimmunol	2010
16924681	Increase in beta1-6 GlcNAc branching caused by N-acetylglucosaminyltransferase V directs integrin beta1 stability in human hepatocellular carcinoma cell line SMMC-7721 Zha, X, Wu, G, Cai, X, Liang, Y, Zhang, W, Jin, J, Yang, Y, Li, Z, Wang, L, Fang, Z	J Cell Biochem	2007
10395745	Characterization of UDP-N-acetylglucosamine:alpha-6-d-mannoside beta-1,6-N-acetylglucosaminyltransferase V from a human hepatoma cell line Hep3B Kim, CH, Lee, YC, Cho, TJ, Park, C, Jin, UH	Arch Biochem Biophys	1999