Plasma membrane-associated LRP2 (megalin, glycoprotein 330) complexed with LDLRAP1 (Low density lipoprotein receptor adapter protein 1, also known as ARH, Autosomal recessive hypercholesterolemia protein) in renal proximal tubule epithelial cells binds TCN2:RCbl (transcobalamin 2 protein bound to cobalamins (RCbl)) (Moestrup et al. 1996; Nagai et al. 2003; Shah et al. 2013). LRP2 is a member of the low density lipoprotein receptor family (Kounnas et al. 1995, Hjalm et al. 1996).
Takeda, T, Meerloo, T, Nagai, M, Farquhar, MG
Brewer, BH, Stefansson, S, Harmony, JA, Loukinova, EB, Kounnas, MZ, Strickland, DK, Argraves, WS
Lundgren, S, Murray, E, Larsson, M, Crumley, G, Hellman, P, Akerstrom, G, Juhlin, C, Ek, B, Morse, B, Davis, H, Rask, L, Onyango, I, Harazim, W, Hjalm, G
Taupin, V, Shah, M, Farquhar, MG, Baterina, OY
Verroust, PJ, Birn, H, Sim, RB, Moestrup, SK, Christensen, EI, Fischer, PB, Nexø, E, Petersen, CM
cargo receptor activity of LRP2:LDLRAP1 [plasma membrane]
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