LRP2 binds extracellular TCN2:RCbl

Stable Identifier
Reaction [transition]
Homo sapiens
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Plasma membrane-associated LRP2 (megalin, glycoprotein 330) complexed with LDLRAP1 (Low density lipoprotein receptor adapter protein 1, also known as ARH, Autosomal recessive hypercholesterolemia protein) in renal proximal tubule epithelial cells binds TCN2:RCbl (transcobalamin 2 protein bound to cobalamins (RCbl)) (Moestrup et al. 1996; Nagai et al. 2003; Shah et al. 2013). LRP2 is a member of the low density lipoprotein receptor family (Kounnas et al. 1995, Hjalm et al. 1996).

Literature References
PubMed ID Title Journal Year
14528014 The adaptor protein ARH escorts megalin to and through endosomes

Takeda, T, Meerloo, T, Nagai, M, Farquhar, MG

Mol Biol Cell 2003
7768901 Identification of glycoprotein 330 as an endocytic receptor for apolipoprotein J/clusterin

Brewer, BH, Stefansson, S, Harmony, JA, Loukinova, EB, Kounnas, MZ, Strickland, DK, Argraves, WS

J Biol Chem 1995
8706697 Cloning and sequencing of human gp330, a Ca(2+)-binding receptor with potential intracellular signaling properties

Lundgren, S, Murray, E, Larsson, M, Crumley, G, Hellman, P, Akerstrom, G, Juhlin, C, Ek, B, Morse, B, Davis, H, Rask, L, Onyango, I, Harazim, W, Hjalm, G

Eur J Biochem 1996
23836931 ARH directs megalin to the endocytic recycling compartment to regulate its proteolysis and gene expression

Taupin, V, Shah, M, Farquhar, MG, Baterina, OY

J Cell Biol 2013
8710919 Megalin-mediated endocytosis of transcobalamin-vitamin-B12 complexes suggests a role of the receptor in vitamin-B12 homeostasis

Verroust, PJ, Birn, H, Sim, RB, Moestrup, SK, Christensen, EI, Fischer, PB, Nexø, E, Petersen, CM

Proc Natl Acad Sci U S A 1996
Catalyst Activity

cargo receptor activity of LRP2:LDLRAP1 [plasma membrane]

Orthologous Events
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