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Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin
Stable Identifier
R-HSA-9759549
Type
Reaction [uncertain]
Species
Homo sapiens
Compartment
cytosol
Synonyms
2 cob(I)alamin + H(+) + NAD(+) => 2 cob(II)alamin + NADH
ReviewStatus
5/5
Locations in the PathwayBrowser
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Metabolism (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Cobalamin (Cbl, vitamin B12) transport and metabolism (Homo sapiens)
Cobalamin (Cbl) metabolism (Homo sapiens)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Homo sapiens)
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Cob(I)alamin bound to MMACHC (Methylmalonic aciduria and homocystinuria type C protein, aka cblC protein) is oxidized to cob(II)alamin. Possible mechanisms for this conversion have been described (Banerjee et al. 2021). The reaction is annotated here without an enzyme catalyst; its chemistry is inferred from that of the bacterial system described by Walker et al. (1969).
Literature References
PubMed ID
Title
Journal
Year
33797888
Redox-Linked Coordination Chemistry Directs Vitamin B
12
Trafficking
Gouda, H
,
Pillay, S
,
Banerjee, R
Acc Chem Res
2021
4390543
Enzymatic conversion of vitamin B 12a to adenosyl-B 12: evidence for the existence of two separate reducing systems
Walker, GA
,
Murphy, S
,
Huennekens, FM
Arch Biochem Biophys
1969
Participants
Input
H+ [cytosol]
x 2
MMACHC:cob(I)alamin [cytosol]
(Homo sapiens)
NAD+ [cytosol]
Output
x 2
MMACHC:cob(II)alamin [cytosol]
(Homo sapiens)
NADH [cytosol]
Participates
as an event of
Cobalamin (Cbl) metabolism (Homo sapiens)
Orthologous Events
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Bos taurus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Caenorhabditis elegans)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Canis familiaris)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Danio rerio)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Dictyostelium discoideum)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Gallus gallus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Mus musculus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Rattus norvegicus)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Sus scrofa)
Cob(I)alamin bound to MMACHC is oxidized to cob(II)alamin (Xenopus tropicalis)
Authored
Jassal, B (2007-04-24)
Reviewed
Hill, DP (2022-02-14)
Created
D'Eustachio, P (2021-12-06)
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