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RNF19B [cytosol]
Stable Identifier
R-HSA-975969
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase RNF19B, RN19B_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF19B [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q6ZMZ0 RNF19B
Gene Names
RNF19B, IBRDC3, NKLAM
Chain
chain:1-732
Reference Genes
BioGPS Gene:127544 RNF19B
COSMIC (genes):RNF19B RNF19B
CTD Gene:127544 RNF19B
dbSNP Gene:127544 RNF19B
ENSEMBL:ENSG00000116514 RNF19B
ENSEMBL_homo_sapiens_GENE:ENSG00000116514.17 RNF19B
HGNC:26886 RNF19B
KEGG Gene (Homo sapiens):127544 RNF19B
Monarch:127544 RNF19B
NCBI Gene:127544 RNF19B
OMIM:610872 RNF19B
UCSC:Q6ZMZ0 RNF19B
Reference Transcript
RefSeq:NM_001127361.2 RNF19B
RefSeq:NM_001300826.1 RNF19B
RefSeq:NM_153341.3 RNF19B
RefSeq:XM_006710356.2 RNF19B
Other Identifiers
11725917_s_at
127544
16684812
213038_PM_at
213038_at
2405317
2405318
2405319
2405320
2405321
2405322
2405323
2405324
2405326
2405327
2405328
2405329
2405330
2405331
2405338
2405339
2405340
2405341
2405342
2405343
36564_PM_at
36564_at
7914603
A_23_P321388
GO:0000151
GO:0000209
GO:0002250
GO:0002376
GO:0003824
GO:0004842
GO:0005515
GO:0005737
GO:0005764
GO:0005773
GO:0005783
GO:0005789
GO:0005829
GO:0006511
GO:0008270
GO:0016020
GO:0016567
GO:0016740
GO:0030163
GO:0031624
GO:0032436
GO:0036211
GO:0042267
GO:0043130
GO:0043226
GO:0044194
GO:0046872
GO:0051865
GO:0061630
GO:0098542
GO:0140096
HMNXSV003028799
HMNXSV003049215
Hs.64239.0.A1_3p_at
Hs.64239.0.A1_3p_s_at
ILMN_1682081
PH_hs_0026633
TC01002478.hg
Participates
as a member of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Rnf19b [cytosol]
(Rattus norvegicus)
RNF19B [cytosol]
(Bos taurus)
RNF19B [cytosol]
(Caenorhabditis elegans)
RNF19B [cytosol]
(Canis familiaris)
RNF19B [cytosol]
(Danio rerio)
RNF19B [cytosol]
(Dictyostelium discoideum)
RNF19B [cytosol]
(Gallus gallus)
RNF19B [cytosol]
(Mus musculus)
RNF19B [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_006710419.1
,
NP_699172.2
,
NP_001287755.1
,
NP_001120833.1
OpenTargets
ENSG00000116514
GeneCards
Q6ZMZ0
HPA
ENSG00000116514-RNF19B
Ensembl
ENSP00000362555
,
ENSP00000235150
,
ENSG00000116514
,
ENST00000356990
,
ENST00000235150
,
ENST00000373456
,
ENSP00000349482
PRO
Q6ZMZ0
Pharos - Targets
Q6ZMZ0
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9NWZ5 UCKL1
1
UCKL1 [cytosol]
(R-HSA-8954322)
0.602
4
UniProt:P01375 TNF
5
TNF(52-76) [extracellular region]
(R-HSA-8863375)
TNF(1-34) [plasma membrane]
(R-HSA-8863367)
TNF(1-76) [plasma membrane]
(R-HSA-8863120)
TNF(77-233) [extracellular region]
(R-HSA-976821)
TNF(1-233) [plasma membrane]
(R-HSA-66220)
0.556
3
UniProt:O14653 GOSR2
4
GOSR2 [endoplasmic reticulum membrane]
(R-HSA-5689451)
GOSR2 [ER to Golgi transport vesicle membrane]
(R-HSA-5689800)
GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-535472)
GOSR2 [Golgi membrane]
(R-HSA-6807755)
0.556
3
UniProt:P14324 FDPS
1
FDPS [cytosol]
(R-HSA-981566)
0.556
3
UniProt:Q9NTJ5 SACM1L
2
SACM1L [endoplasmic reticulum membrane]
(R-HSA-1604637)
SACM1L [Golgi membrane]
(R-HSA-1806242)
0.556
3
UniProt:Q15436 SEC23A
4
p-S738,T744 SEC23A [cytosol]
(R-HSA-5685740)
SEC23A [ER to Golgi transport vesicle membrane]
(R-HSA-204024)
SEC23A [cytosol]
(R-HSA-203972)
SEC23A [endoplasmic reticulum membrane]
(R-HSA-203976)
0.556
3
UniProt:Q8TAF3 WDR48
3
p-12Y-WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol]
(R-HSA-9673645)
WDR48(1-323)-PDGFRB(559-1106) fusion [cytosol]
(R-HSA-9673617)
WDR48 [nucleoplasm]
(R-HSA-419549)
0.527
2
UniProt:P42336 PIK3CA
20
PIK3CA H1047L [cytosol]
(R-HSA-1500714)
PIK3CA H1047R [cytosol]
(R-HSA-1500716)
PIK3CA M1043I [cytosol]
(R-HSA-1500719)
PIK3CA M1043T [cytosol]
(R-HSA-2395934)
PIK3CA M1043V [cytosol]
(R-HSA-2395932)
PIK3CA H1047Y [cytosol]
(R-HSA-1500720)
PIK3CA E542K [cytosol]
(R-HSA-1500701)
PIK3CA Q546K [cytosol]
(R-HSA-1500705)
PIK3CA E545A [cytosol]
(R-HSA-2362355)
PIK3CA E545K [cytosol]
(R-HSA-1500706)
PIK3CA E545Q [cytosol]
(R-HSA-2362362)
PIK3CA Q546E [cytosol]
(R-HSA-2362383)
PIK3CA E545V [cytosol]
(R-HSA-2362365)
PIK3CA E542V [cytosol]
(R-HSA-2328074)
PIK3CA Q546L [cytosol]
(R-HSA-2362375)
PIK3CA E545G [cytosol]
(R-HSA-1500709)
PIK3CA Q546H [cytosol]
(R-HSA-2362374)
PIK3CA Q546R [cytosol]
(R-HSA-2362373)
PIK3CA Q546P [cytosol]
(R-HSA-1500695)
PIK3CA E542Q [cytosol]
(R-HSA-2328003)
0.527
2
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.527
2
UniProt:P68036 UBE2L3
4
Ub-C86-UBE2L3 [nucleoplasm]
(R-HSA-8864226)
UBE2L3 [nucleoplasm]
(R-HSA-8852056)
UBE2L3 [cytosol]
(R-HSA-947631)
Ub-C86-UBE2L3 [cytosol]
(R-HSA-8864201)
0.524
2
UniProt:O14933 UBE2L6
2
UBE2L6 [cytosol]
(R-HSA-936014)
UBE2L6 [nucleoplasm]
(R-HSA-5653666)
0.524
3
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