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SMURF1 [cytosol]
Stable Identifier
R-HSA-975972
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin-protein ligase SMURF1, SMUF1_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional regulation by RUNX2 (Homo sapiens)
Regulation of RUNX2 expression and activity (Homo sapiens)
RUNX2 binds SMURF1 (Homo sapiens)
RUNX2:SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 polyubiquitinates RUNX2 (Homo sapiens)
RUNX2:SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Hedgehog (Homo sapiens)
Hedgehog 'on' state (Homo sapiens)
SMURF1/2 bind PTCH1 (Homo sapiens)
PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1/2 dissociates from ub-PTCH1 (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
ub-PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1/2 ubiquitinates PTCH1 (Homo sapiens)
PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
ub-PTCH1:SMURF [ciliary membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by BMP (Homo sapiens)
I-Smad binds to type I receptor, preventing Smad1/5/8 from being activated (Homo sapiens)
BMP:p-BMPR:I-SMAD:SMURF [plasma membrane] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
I-SMAD:SMURF [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Ubiquitin-dependent degradation controls basal levels of R-Smad1/5/8 (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Signaling by TGF-beta Receptor Complex (Homo sapiens)
TGF-beta receptor signaling activates SMADs (Homo sapiens)
Downregulation of TGF-beta receptor signaling (Homo sapiens)
SMAD7:SMURF complex binds to phosphorylated TGFBR1 (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMAD7:SMURF1 complex is exported to the cytosol (Homo sapiens)
SMAD7:SMURF1 [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURFs/NEDD4L ubiquitinate phosphorylated TGFBR1 and SMAD7 (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
TGFB1:TGFBR2:p-TGFBR1:SMAD7:SMURF/NEDD4L [plasma membrane] (Homo sapiens)
SMAD7:SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition) (Homo sapiens)
Disassembly of tight junctions (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 binds phosphorylated PARD6A (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1 ubiquitinates RHOA (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:Ub-RHOA:SMURF1 [cell junction] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
Signaling by WNT (Homo sapiens)
Beta-catenin independent WNT signaling (Homo sapiens)
PCP/CE pathway (Homo sapiens)
Asymmetric localization of PCP proteins (Homo sapiens)
SMURF1/2 are recruited to the DVL2:PARD6A complex (Homo sapiens)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF1/2 ubiquitinates PRICKLE1 (Homo sapiens)
PARD6A:pp-DVL2:SMURF [plasma membrane] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
SMURF [cytosol] (Homo sapiens)
SMURF1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9HCE7 SMURF1
Gene Names
SMURF1, KIAA1625
Chain
chain:1-757
Reference Genes
BioGPS Gene:57154 SMURF1
COSMIC (genes):SMURF1 SMURF1
CTD Gene:57154 SMURF1
dbSNP Gene:57154 SMURF1
ENSEMBL:ENSG00000198742 SMURF1
ENSEMBL:ENSG00000198742.10 SMURF1
ENSEMBL:ENSG00000284126.1 SMURF1
HGNC:16807 SMURF1
KEGG Gene (Homo sapiens):57154 SMURF1
Monarch:57154 SMURF1
NCBI Gene:57154 SMURF1
OMIM:605568 SMURF1
UCSC:Q9HCE7 SMURF1
Reference Transcript
RefSeq:NM_181349.2 SMURF1
RefSeq:NM_020429.2 SMURF1
RefSeq:NM_001199847.1 SMURF1
Other Identifiers
11722957_a_at
11736974_a_at
17060186
212666_PM_at
212666_at
212668_PM_at
212668_at
215458_PM_s_at
215458_s_at
3063088
3063089
3063090
3063091
3063092
3063093
3063094
3063096
3063097
3063098
3063100
3063102
3063105
3063107
3063109
3063111
3063114
3063115
3063116
3063117
3063118
3063119
3063120
3063122
3063124
3063156
3063157
37504_at
57154
63399_at
8141241
A_23_P353316
A_23_P398254
GE56944
GO:0000209
GO:0003824
GO:0004842
GO:0005515
GO:0005543
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005829
GO:0005886
GO:0006511
GO:0006611
GO:0006886
GO:0006913
GO:0006914
GO:0007398
GO:0008289
GO:0016020
GO:0016567
GO:0016740
GO:0023052
GO:0030154
GO:0030163
GO:0030424
GO:0030509
GO:0030512
GO:0030514
GO:0030579
GO:0032801
GO:0034394
GO:0036211
GO:0043025
GO:0043161
GO:0043226
GO:0045773
GO:0048185
GO:0048856
GO:0060071
GO:0061024
GO:0061630
GO:0061736
GO:0061753
GO:0070062
GO:0070411
GO:0070412
GO:0071211
GO:0072659
GO:0140096
GO:1903861
GO:2000060
HMNXSV003028849
Hs.119120.0.S2_3p_at
Hs.119120.1.S1_3p_a_at
ILMN_1756615
ILMN_1779492
PH_hs_0040932
TC07001639.hg
Participates
as an output of
SMURF1 gene expression is stimulated by RUNX2 (Homo sapiens)
SMURF1 polyubiquitinates RUNX2 (Homo sapiens)
SMURF1 ubiquitinates Smad7 and phosphorylated TGFBR1 (Homo sapiens)
as an input of
RUNX2 binds SMURF1 (Homo sapiens)
SMURF1 binds phosphorylated PARD6A (Homo sapiens)
as a component of
RUNX2:SMURF1 [cytosol] (Homo sapiens)
Tight Junction Complex:TGFB1:TGFBR2:p-TGFBR1:p-PARD6A:RHOA:SMURF1 [plasma membrane] (Homo sapiens)
Smad7:SMURF1 [cytosol] (Homo sapiens)
SMAD7:SMURF1 [cytosol] (Homo sapiens)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
as a member of
SMURF [cytosol] (Homo sapiens)
SMURF/NEDD4L [cytosol] (Homo sapiens)
Other forms of this molecule
SMURF1 [nucleoplasm]
Inferred To
SMURF1 [cytosol]
(Bos taurus)
SMURF1 [cytosol]
(Canis familiaris)
SMURF1 [cytosol]
(Danio rerio)
SMURF1 [cytosol]
(Gallus gallus)
SMURF1 [cytosol]
(Sus scrofa)
pub1 [cytosol]
(Schizosaccharomyces pombe)
RSP5 [cytosol]
(Saccharomyces cerevisiae)
Smurf [cytosol]
(Drosophila melanogaster)
pub3 [cytosol]
(Schizosaccharomyces pombe)
smurf1 [cytosol]
(Xenopus tropicalis)
Smurf1 [cytosol]
(Mus musculus)
Smurf1 [cytosol]
(Rattus norvegicus)
pub2 [cytosol]
(Schizosaccharomyces pombe)
Homologues of SMURF1 [cytosol]
(Schizosaccharomyces pombe)
Cross References
RefSeq
NP_001186776.1
,
NP_851994.1
,
NP_065162.1
OpenTargets
ENSG00000198742
IntEnz
2.3.2.26
GeneCards
Q9HCE7
HPA
ENSG00000198742-SMURF1
Ensembl
ENST00000361125
,
ENSP00000354621
,
ENSP00000355326
,
ENST00000638461
,
ENST00000638647
,
ENSP00000492201
,
ENSP00000491036
,
ENST00000361368
,
ENSG00000284126
,
ENSG00000198742
PRO
Q9HCE7
Pharos - Targets
Q9HCE7
HMDB Protein
HMDBP09298
PDB
2LTX
,
2LB0
,
2LAZ
,
2LB1
,
3PYC
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q9H469 FBXL15
1
FBXL15 [cytosol]
(R-HSA-8862625)
0.645
6
UniProt:Q53GL0 PKHO1
0.623
2
UniProt:P61289 PSME3
2
PSME3 [nucleoplasm]
(R-HSA-174310)
PSME3 [cytosol]
(R-HSA-68816)
0.593
5
UniProt:Q15797 SMAD1
4
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
SMAD1 [cytosol]
(R-HSA-201468)
0.573
2
UniProt:Q9Y5W3 KLF2
0.508
2
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