Reactome | SMURF1 [cytosol]

SMURF1 [cytosol]

Stable Identifier

R-HSA-975972

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase SMURF1, SMUF1_HUMAN

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Locations in the PathwayBrowser for interactor UniProt:P31749 AKT1

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External Reference Information

External Reference

UniProt:Q9HCE7 SMURF1

Gene Names

SMURF1, KIAA1625

Chain

chain:1-757

Reference Genes

BioGPS Gene:57154 SMURF1

COSMIC (genes):SMURF1 SMURF1

CTD Gene:57154 SMURF1

dbSNP Gene:57154 SMURF1

ENSEMBL:ENSG00000198742 SMURF1

HGNC:16807 SMURF1

KEGG:hsa:57154 SMURF1

Monarch:57154 SMURF1

NCBI Gene:57154 SMURF1

OMIM:605568 SMURF1

UCSC:Q9HCE7 SMURF1

Reference Transcript

Participates

as an output of

as an input of

as a component of

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

as a member of

Other forms of this molecule

SMURF1 [nucleoplasm]

Inferred To

SMURF1 [cytosol] (Bos taurus)

SMURF1 [cytosol] (Canis familiaris)

SMURF1 [cytosol] (Gallus gallus)

SMURF1 [cytosol] (Sus scrofa)

pub1 [cytosol] (Schizosaccharomyces pombe)

RSP5 [cytosol] (Saccharomyces cerevisiae)

Smurf [cytosol] (Drosophila melanogaster)

pub3 [cytosol] (Schizosaccharomyces pombe)

smurf1 [cytosol] (Danio rerio)

smurf1 [cytosol] (Xenopus tropicalis)

Smurf1 [cytosol] (Mus musculus)

Smurf1 [cytosol] (Rattus norvegicus)

pub2 [cytosol] (Schizosaccharomyces pombe)

Homologues of SMURF1 [cytosol] (Schizosaccharomyces pombe)

Cross References

RefSeq

NP_065162.1, NP_851994.1, NP_001186776.1

ENSEMBL

ENSG00000198742, ENST00000361125, ENST00000361368, ENSP00000355326, ENSP00000354621

OpenTargets

ENSG00000198742

IntEnz

2.3.2.26

GeneCards

SMURF1

HPA

ENSG00000198742-SMURF1

PRO

Q9HCE7

Pharos - Targets

Q9HCE7

HMDB Protein

HMDBP09298

PDB

2LTX, 3PYC, 2LB1, 2LB0, 2LAZ

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9H469 FBXL15	1	FBXL15 [cytosol] (R-HSA-8862625)	0.645	6
UniProt:Q53GL0 PKHO1			0.623	2
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.593	5
UniProt:Q15797 SMAD1	4	SMAD1 [cytosol] (R-HSA-201468) p-S463,S465-SMAD1 [cytosol] (R-HSA-201464) p-S463,S465-SMAD1 [nucleoplasm] (R-HSA-201483) Ub-SMAD1 [cytosol] (R-HSA-6782768)	0.573	2
UniProt:Q9Y5W3 KLF2			0.508	2
UniProt:P31749 AKT1	14	p-T308,S473-AKT1 [nucleoplasm] (R-HSA-198357) p-T308,S473-AKT1 [cytosol] (R-HSA-198356) p-S473-AKT1 [plasma membrane] (R-HSA-377265) AKT1 [plasma membrane] (R-HSA-199416) AKT1 [cytosol] (R-HSA-58252) p-T308-AKT1 [cytosol] (R-HSA-198634) p-T308,S473-AKT1 [plasma membrane] (R-HSA-199430) p-Y315,Y326-AKT1 [cytosol] (R-HSA-8848757) p-S473-AKT1 [cytosol] (R-HSA-9841264) AKT1 E17K [plasma membrane] (R-HSA-1500573) p-S473-AKT1 E17K [plasma membrane] (R-HSA-2243944) AKT1 E17K [cytosol] (R-HSA-2219526) p-T308,S473-AKT1 E17K [cytosol] (R-HSA-2243935) p-T308,S473-AKT1 E17K [nucleoplasm] (R-HSA-2399994)	0.471	2

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