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RNF4 [cytosol]
Stable Identifier
R-HSA-975974
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
E3 ubiquitin ligase RNF4, RNF4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Adaptive Immune System (Homo sapiens)
Class I MHC mediated antigen processing & presentation (Homo sapiens)
Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
Polyubiquitination of substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
Release of E3 from polyubiquitinated substrate (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
E3:Ub:substrate [cytosol] (Homo sapiens)
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
RNF4 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P78317 RNF4
Gene Names
RNF4, SNURF, RES4-26
Chain
chain:1-190
Reference Genes
BioGPS Gene:6047 RNF4
COSMIC (genes):RNF4 RNF4
COSMIC (genes):SNURF RNF4
CTD Gene:6047 RNF4
dbSNP Gene:6047 RNF4
ENSEMBL:ENSG00000063978 RNF4
HGNC:10067 RNF4
KEGG:hsa:6047 RNF4
Monarch:6047 RNF4
NCBI Gene:6047 RNF4
OMIM:602850 RNF4
UCSC:P78317 RNF4
Reference Transcript
RefSeq:NM_001185010.2 RNF4
RefSeq:NM_001185009.2 RNF4
RefSeq:NM_002938.4 RNF4
Other Identifiers
11757006_s_at
11757883_s_at
16964142
212696_PM_s_at
212696_s_at
2715427
2715428
2715429
2715441
2715442
2715443
2715444
2715445
2715446
2715447
2715450
2715451
2715452
2715453
2715455
2715456
2715457
2715458
2715459
2715460
2715464
2715465
2715466
2715467
2715468
2715469
2715470
35777_at
4047577
4047578
4047579
4047580
4047581
4047583
4047584
6047
8093590
AB000468_at
A_14_P121439
A_23_P167313
GE53016
GO:0003677
GO:0003824
GO:0004842
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0006355
GO:0008270
GO:0016567
GO:0016604
GO:0016605
GO:0016740
GO:0030163
GO:0030374
GO:0031491
GO:0032184
GO:0042802
GO:0043161
GO:0043226
GO:0045893
GO:0045944
GO:0046685
GO:0046872
GO:0051865
GO:0060090
GO:0061630
GO:0070534
GO:0070936
GO:0070979
GO:0085020
GO:0090169
GO:0090234
GO:0120186
GO:0140096
GO:0140110
GO:1990752
HMNXSV003035504
Hs.66394.1.A1_3p_a_at
ILMN_1687941
ILMN_1739318
ILMN_2142695
TC04002910.hg
Participates
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Other forms of this molecule
RNF4 [nucleoplasm]
Inferred To
rfp2 [cytosol]
(Schizosaccharomyces pombe)
RNF4 [cytosol]
(Bos taurus)
RNF4 [cytosol]
(Canis familiaris)
RNF4 [cytosol]
(Gallus gallus)
RNF4 [cytosol]
(Mus musculus)
RNF4 [cytosol]
(Rattus norvegicus)
RNF4 [cytosol]
(Sus scrofa)
rnf4 [cytosol]
(Danio rerio)
rnf4 [cytosol]
(Xenopus tropicalis)
mip1-2 [cytosol]
(Dictyostelium discoideum)
dgrn [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_002929.1
,
NP_001171938.1
,
NP_001171939.1
OpenTargets
ENSG00000063978
ENSEMBL
ENSP00000426615
,
ENST00000506706
,
ENST00000314289
,
ENSP00000315212
,
ENST00000511859
,
ENSP00000424076
,
ENSP00000426503
,
ENSP00000446369
,
ENST00000511600
,
ENST00000541204
HPA
ENSG00000063978-RNF4
PRO
P78317
Pharos - Targets
P78317
PDB
2XEU
,
2EA6
,
4PPE
Interactors (20)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q12933 TRAF2
5
TRAF2 [cytosol]
(R-HSA-66370)
PolyUb-TRAF2 [cytosol]
(R-HSA-6782848)
K63polyUb-TRAF2 [cytosol]
(R-HSA-8862193)
K63polyUb-TRAF2 [nucleoplasm]
(R-HSA-8862194)
TRAF2 [nucleoplasm]
(R-HSA-8862199)
0.556
3
UniProt:Q12846 STX4
4
STX4 [plasma membrane]
(R-HSA-181519)
STX4 [phagocytic vesicle membrane]
(R-HSA-2029044)
STX4 [cytosol]
(R-HSA-114505)
p-STX4 [cytosol]
(R-HSA-114681)
0.556
3
UniProt:O95231 VENTX
1
VENTX [nucleoplasm]
(R-HSA-8853887)
0.556
3
UniProt:Q99836 MYD88
8
MyD88 R196C [cytosol]
(R-HSA-5602329)
MyD88 E52del [cytosol]
(R-HSA-5602451)
MyD88 L93P [cytosol]
(R-HSA-5602612)
MyD88 S34Y [cytosol]
(R-HSA-5602521)
MyD88 E65del [cytosol]
(R-HSA-5602598)
MYD88 [endosome membrane]
(R-HSA-975123)
MYD88 [plasma membrane]
(R-HSA-937017)
MYD88 [cytosol]
(R-HSA-166059)
0.556
3
UniProt:P13500 CCL2
1
CCL2 [extracellular region]
(R-HSA-443967)
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:Q16623 STX1A
5
STX1A [plasma membrane]
(R-HSA-449128)
STX1A(?-288) [plasma membrane]
(R-HSA-5246518)
STX1A(1-?) [cytosol]
(R-HSA-3065964)
STX1A [cytosol]
(R-HSA-9609866)
STX1A [endoplasmic reticulum membrane]
(R-HSA-9609878)
0.556
3
UniProt:Q13114 TRAF3
4
K63polyUb-TRAF3 [cytosol]
(R-HSA-936402)
TRAF3 [cytosol]
(R-HSA-914241)
K48polyUb-TRAF3 [cytosol]
(R-HSA-936556)
TRAF3 R118W [cytosol]
(R-HSA-5602321)
0.556
3
UniProt:Q9UER7 DAXX
13
DAXX [nucleoplasm]
(R-HSA-3222068)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
0.556
3
UniProt:Q07817 BCL2L1
2
BCL2L1 [cytosol]
(R-HSA-50771)
BCL2L1 [mitochondrial outer membrane]
(R-HSA-114236)
0.556
3
UniProt:O75344 FKBP6
2
FKBP6 [nucleoplasm]
(R-HSA-912512)
FKBP6 [cytosol]
(R-HSA-5601923)
0.556
3
UniProt:Q13838 DDX39B
2
DDX39B [nucleoplasm]
(R-HSA-8849139)
DDX39B [cytosol]
(R-HSA-9715154)
0.556
3
UniProt:Q08426 EHHADH
2
EHHADH [peroxisomal matrix]
(R-HSA-400155)
EHHADH [cytosol]
(R-HSA-9033147)
0.556
3
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
SUMO1 [nucleoplasm]
(R-HSA-877304)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
0.556
3
UniProt:P15336 ATF2
2
p-T69,T71-ATF2 [nucleoplasm]
(R-HSA-450243)
ATF2 [nucleoplasm]
(R-HSA-450336)
0.556
3
UniProt:P60709 ACTB
5
ACTB [plasma membrane]
(R-HSA-196016)
ACTB [lysosomal membrane]
(R-HSA-196160)
ACTB [cytosol]
(R-HSA-201861)
ACTB [nucleoplasm]
(R-HSA-3321990)
Unfolded ACTB [cytosol]
(R-HSA-390462)
0.556
3
UniProt:Q13158 FADD
1
FADD [cytosol]
(R-HSA-54639)
0.556
5
UniProt:P11474 ESRRA
1
ESRRA [nucleoplasm]
(R-HSA-446159)
0.556
3
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.556
3
UniProt:P63279 UBE2I
9
monoSUMO1-K14-UBE2I [nucleoplasm]
(R-HSA-4085358)
UBE2I [nuclear envelope]
(R-HSA-4655408)
SUMO2-C93-UBE2I [cytosol]
(R-HSA-4656944)
SUMO3-C93-UBE2I [nucleoplasm]
(R-HSA-3730629)
UBE2I [nucleoplasm]
(R-HSA-912481)
SUMO1-C93-UBE2I [nucleoplasm]
(R-HSA-3730617)
SUMO2-C93-UBE2I [nucleoplasm]
(R-HSA-3730619)
SUMO1-C93-UBE2I [cytosol]
(R-HSA-4656909)
UBE2I [cytosol]
(R-HSA-4655342)
0.553
2
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