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RNF41 [cytosol]
Stable Identifier
R-HSA-975977
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
NRDP1, E3 ubiquitin-protein ligase NRDP1, RNF41_HUMAN
Locations in the PathwayBrowser for interactor UniProt:Q9NPF7 IL23A
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by ERBB2 (Homo sapiens)
Downregulation of ERBB2 signaling (Homo sapiens)
Downregulation of ERBB2:ERBB3 signaling (Homo sapiens)
Deubiquitination of RNF41 by P-USP8 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
ERBB3 binds RNF41 ubiquitin ligase (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
RNF41 ubiquitinates ERBB3 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
RNF41 ubiquitinates activated ERBB3 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
Self-ubiquitination of RNF41 (Homo sapiens)
RNF41 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9H4P4 RNF41
Gene Names
RNF41, FLRF, NRDP1, SBBI03
Chain
chain:1-317
Reference Genes
BioGPS Gene:10193 RNF41
COSMIC (genes):RNF41 RNF41
CTD Gene:10193 RNF41
dbSNP Gene:10193 RNF41
ENSEMBL:ENSG00000181852 RNF41
ENSEMBL_homo_sapiens_GENE:ENSG00000181852.18 RNF41
HGNC:18401 RNF41
KEGG Gene (Homo sapiens):10193 RNF41
Monarch:10193 RNF41
NCBI Gene:10193 RNF41
OMIM:620051 RNF41
UCSC:Q9H4P4 RNF41
Reference Transcript
RefSeq:NM_001242826.1 RNF41
RefSeq:XM_011537734.2 RNF41
RefSeq:NM_194359.2 RNF41
RefSeq:XM_011537735.2 RNF41
RefSeq:NM_005785.3 RNF41
RefSeq:XM_005268561.4 RNF41
RefSeq:NM_194358.2 RNF41
Other Identifiers
10193
11721953_a_at
11721954_s_at
11755859_a_at
16765945
201961_PM_s_at
201961_s_at
201962_PM_s_at
201962_s_at
235459_PM_at
235459_at
3457520
3457522
3457524
3457525
3457526
3457527
3457528
3457529
3457530
3457531
3457535
3457536
3457537
3457538
3457540
3457541
3457542
3457543
3457544
40047_at
75112_at
7964021
A_23_P98884
A_24_P244470
A_24_P630875
GE54704
GE684812
GE827543
GO:0000209
GO:0002376
GO:0003824
GO:0004842
GO:0005128
GO:0005135
GO:0005515
GO:0005783
GO:0005829
GO:0006914
GO:0006915
GO:0007005
GO:0008270
GO:0008285
GO:0010498
GO:0012501
GO:0016567
GO:0016740
GO:0019904
GO:0023052
GO:0030154
GO:0030163
GO:0030336
GO:0030971
GO:0031267
GO:0036211
GO:0042802
GO:0043226
GO:0043408
GO:0045619
GO:0045637
GO:0045732
GO:0046872
GO:0048471
GO:0048856
GO:0048870
GO:0051865
GO:0051896
GO:0061630
GO:0071782
GO:0097191
GO:0140096
GO:1901525
GO:2000377
GO:2000379
HMNXSV003007892
Hs.136316.0.A1_3p_at
Hs.153639.0.S1_3p_a_at
ILMN_1700345
ILMN_1808095
PH_hs_0040605
TC12001598.hg
TC12002908.hg
g5032070_3p_a_at
Participates
as an input of
RNF41 binds neuregulin-activated ERBB3 (Homo sapiens)
ERBB3 binds RNF41 ubiquitin ligase (Homo sapiens)
Self-ubiquitination of RNF41 (Homo sapiens)
as an output of
RNF41 ubiquitinates activated ERBB3 (Homo sapiens)
RNF41 ubiquitinates ERBB3 (Homo sapiens)
Deubiquitination of RNF41 by P-USP8 (Homo sapiens)
as a component of
NRG1/2:p-10Y-ERBB3:p-ERBB2:RNF41 [plasma membrane] (Homo sapiens)
ERBB3:RNF41 [plasma membrane] (Homo sapiens)
Ub-RNF41 [cytosol] (Homo sapiens)
as a candidate of
E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
Inferred To
Rnf41 [cytosol]
(Mus musculus)
Rnf41 [cytosol]
(Rattus norvegicus)
Ghost homologue of RNF41 [cytosol]
(Canis familiaris)
RNF41 [cytosol]
(Bos taurus)
RNF41 [cytosol]
(Dictyostelium discoideum)
RNF41 [cytosol]
(Gallus gallus)
RNF41 [cytosol]
(Sus scrofa)
elgi [cytosol]
(Drosophila melanogaster)
rnf41 [cytosol]
(Danio rerio)
Cross References
RefSeq
NP_919339.1
,
NP_001229755.1
,
NP_919340.1
,
XP_011536036.1
,
XP_005268618.1
,
XP_011536037.1
,
NP_005776.1
OpenTargets
ENSG00000181852
IntEnz
2.3.2.27
GeneCards
Q9H4P4
HPA
ENSG00000181852-RNF41
Ensembl
ENST00000345093
,
ENSG00000181852
,
ENST00000552656
,
ENSP00000342755
,
ENSP00000447303
,
ENST00000615206
,
ENST00000394013
,
ENSP00000484671
,
ENSP00000377581
PRO
Q9H4P4
Pharos - Targets
Q9H4P4
PDB
2FZP
,
2GWF
Interactors (31)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q99614 TTC1
0.871
12
UniProt:Q9NWX5 ASB6
1
ASB6 [cytosol]
(R-HSA-975412)
0.832
9
UniProt:Q86U28 ISCA2
1
ISCA2 [mitochondrial matrix]
(R-HSA-5691207)
0.782
7
UniProt:Q8N1B4 VPS52
1
VPS52 [trans-Golgi network membrane]
(R-HSA-6811029)
0.782
7
UniProt:P35249 RFC4
1
RFC4 [nucleoplasm]
(R-HSA-68429)
0.781
7
UniProt:Q9UHY7 ENOPH1
1
ENOPH1 [cytosol]
(R-HSA-1237187)
0.742
10
UniProt:Q9NX04 AIRIM
0.718
6
UniProt:Q9H4P4 RNF41
1
RNF41 [cytosol]
(R-HSA-975977)
0.668
3
UniProt:Q9GZT4 SRR
1
PXLP-K56-SRR [cytosol]
(R-HSA-9014764)
0.666
7
UniProt:O15049 N4BP3
0.666
6
UniProt:Q8N3F0 MTURN
0.556
3
UniProt:P49723
1
RNR4 [cytosol]
(R-SCE-111792-2)
0.556
3
UniProt:Q8N8B7-2 TCEANC
0.556
3
UniProt:Q66PJ3-3 ARL6IP4
0.556
3
UniProt:Q9NSB8 HOMER2
1
HOMER2 [cytosol]
(R-HSA-6794251)
0.556
3
UniProt:Q7LG56 RRM2B
1
RRM2B [cytosol]
(R-HSA-111792)
0.556
3
UniProt:A0A0C4DG62 A0A0C4DG62
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:P61086 UBE2K
2
UBE2K [cytosol]
(R-HSA-934631)
Ub-C92-UBE2K [cytosol]
(R-HSA-8864200)
0.556
3
UniProt:P54725 RAD23A
1
RAD23A [nucleoplasm]
(R-HSA-5688076)
0.556
3
UniProt:Q9BRK4 LZTS2
0.556
3
UniProt:P13796 LCP1
1
LCP1 [cell junction]
(R-HSA-8950517)
0.527
2
UniProt:Q9Y2Z0 SUGT1
1
SUGT1 [cytosol]
(R-HSA-874107)
0.527
2
UniProt:Q6ZMY9 ZNF517
1
ZNF517 [nucleoplasm]
(R-HSA-1973869)
0.527
2
UniProt:Q15293 RCN1
2
p-RCN1 [endoplasmic reticulum lumen]
(R-HSA-8956989)
RCN1 [endoplasmic reticulum lumen]
(R-HSA-8956758)
0.527
2
UniProt:P09681 GIP
6
GIP(22-153) [endoplasmic reticulum lumen]
(R-HSA-400512)
GIP(22-153) [secretory granule lumen]
(R-HSA-400526)
GIP(52-93) [secretory granule lumen]
(R-HSA-400483)
GIP(54-93) [extracellular region]
(R-HSA-400542)
GIP(1-153) [endoplasmic reticulum lumen]
(R-HSA-400470)
GIP(52-93) [extracellular region]
(R-HSA-400540)
0.527
2
UniProt:Q9NPF7 IL23A
2
IL23A [endoplasmic reticulum lumen]
(R-HSA-8950224)
IL23A [extracellular region]
(R-HSA-447245)
0.527
2
UniProt:Q2KHT3 CL16A
0.527
2
UniProt:Q7RTS1 BHA15
0.527
4
UniProt:P0DTD1-PRO_0000449632 REP
0.527
2
UniProt:Q13325 IFIT5
1
IFIT5 [cytosol]
(R-HSA-9684472)
0.527
2
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