Reactome | ANAPC13 [cytosol]

ANAPC13 [cytosol]

Stable Identifier

R-HSA-975982

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

APC13, Anaphase-promoting complex subunit 13, APC13_HUMAN

Locations in the PathwayBrowser

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Immune System (Homo sapiens)

- Adaptive Immune System (Homo sapiens)
  - Class I MHC mediated antigen processing & presentation (Homo sapiens)
    - Antigen processing: Ubiquitination & Proteasome degradation (Homo sapiens)
      - Interaction of E3 with substrate and E2-Ub complex (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)
      - Polyubiquitination of substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)
      - Release of E3 from polyubiquitinated substrate (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)
        
        E3:K48-polyubiquitinated substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)
      - Transfer of Ub from E2 to substrate and release of E2 (Homo sapiens)
        
        Ag-substrate:E3:E2:Ub [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)
        
        E3:Ub:substrate [cytosol] (Homo sapiens)
        
        E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)
        
        APC/C E3 ligase complex [cytosol] (Homo sapiens)
        
        ANAPC13 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BS18 ANAPC13

Gene Names

ANAPC13

Chain

chain:1-74

Reference Genes

BioGPS Gene:25847 ANAPC13

COSMIC (genes):ANAPC13 ANAPC13

CTD Gene:25847 ANAPC13

dbSNP Gene:25847 ANAPC13

ENSEMBL:ENSG00000129055 ANAPC13

ENSEMBL_homo_sapiens_GENE:ENSG00000129055.13 ANAPC13

HGNC:24540 ANAPC13

KEGG Gene (Homo sapiens):25847 ANAPC13

Monarch:25847 ANAPC13

NCBI Gene:25847 ANAPC13

OMIM:614484 ANAPC13

UCSC:Q9BS18 ANAPC13

Reference Transcript

Other Identifiers

11716625_a_at

11754697_a_at

16959465

209001_PM_s_at

209001_s_at

215282_PM_at

215282_at

25847

2696380

2696381

2696382

2696383

2696386

2696387

2696388

2696389

2696390

2696391

38687_at

8090866

A_32_P16854

GE554395

GE55738

GO:0000278

GO:0005515

GO:0005634

GO:0005680

GO:0007049

GO:0007346

GO:0016567

GO:0022414

GO:0030163

GO:0031145

GO:0036211

GO:0043226

GO:0051301

GO:0051445

GO:0070979

HMNXSV003029508

ILMN_1793894

PH_hs_0005946

TC03001805.hg

g13529286_3p_a_at

Participates

as a component of

APC/C E3 ligase complex [cytosol] (Homo sapiens)

Inferred To

Anapc13 [cytosol] (Mus musculus)

Anapc13 [cytosol] (Rattus norvegicus)

BEST:GH01256 [cytosol] (Drosophila melanogaster)

Ghost homologue of ANAPC13 [cytosol] (Caenorhabditis elegans)

Ghost homologue of ANAPC13 [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of ANAPC13 [cytosol] (Schizosaccharomyces pombe)

ANAPC13 [cytosol] (Bos taurus)

ANAPC13 [cytosol] (Canis familiaris)

ANAPC13 [cytosol] (Dictyostelium discoideum)

ANAPC13 [cytosol] (Gallus gallus)

ANAPC13 [cytosol] (Sus scrofa)

anapc13 [cytosol] (Xenopus tropicalis)

Cross References

RefSeq

NP_001229303.1, NP_001229304.1, NP_056206.1

OpenTargets

ENSG00000129055

HPA

ENSG00000129055-ANAPC13

GeneCards

Q9BS18

Ensembl

ENST00000354910, ENST00000511751, ENSP00000421842, ENSP00000421760, ENST00000514612, ENST00000510994, ENSG00000129055, ENSP00000427327, ENSP00000346987

PRO

Q9BS18

Pharos - Targets

Q9BS18

PDB

6TLJ, 7QE7, 5L9U, 8TAR, 5LCW, 5KHR, 5L9T, 5G04, 6Q6H, 4UI9, 6Q6G, 5KHU, 8TAU, 8PKP, 6TM5, 6TNT

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9JJ66	3	Cdc20 [nucleoplasm] (R-MMU-6783069) Cdc20 [nucleoplasm] (R-MMU-174112) Cdc20 [cytosol] (R-MMU-141412)	0.564	2
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3