Reactome | RNF5 [endoplasmic reticulum membrane]

RNF5 [endoplasmic reticulum membrane]

Stable Identifier

R-HSA-975990

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum membrane

Synonyms

E3 ubiquitin-protein ligase RNF5, RNF5_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q99942 RNF5

Gene Names

RNF5, G16, NG2, RMA1

Chain

initiator methionine:, chain:2-180

Reference Genes

BioGPS Gene:6048 RNF5

COSMIC (genes):RNF5 RNF5

CTD Gene:6048 RNF5

dbSNP Gene:6048 RNF5

ENSEMBL:ENSG00000204308 RNF5

ENSEMBL_homo_sapiens_GENE:ENSG00000183574.12 RNF5

ENSEMBL_homo_sapiens_GENE:ENSG00000204308.8 RNF5

ENSEMBL_homo_sapiens_GENE:ENSG00000223767.5 RNF5

ENSEMBL_homo_sapiens_GENE:ENSG00000225452.5 RNF5

ENSEMBL_homo_sapiens_GENE:ENSG00000227277.9 RNF5

ENSEMBL_homo_sapiens_GENE:ENSG00000228405.5 RNF5

ENSEMBL_homo_sapiens_GENE:ENSG00000228907.5 RNF5

HGNC:10068 RNF5

KEGG Gene (Homo sapiens):6048 RNF5

Monarch:6048 RNF5

NCBI Gene:6048 RNF5

OMIM:602677 RNF5

UCSC:Q99942 RNF5

Reference Transcript

RefSeq:NM_006913.3 RNF5

Other Identifiers

11757623_s_at

17007237

17026393

17028297

17033588

17035866

17038580

17041209

209111_PM_at

209111_at

2903131

2903132

2903133

2903135

2903137

2903139

2903140

2903141

3132181

3132182

3132183

3132184

3132186

3132187

3132188

3132189

3132191

3132192

3132193

3132194

33347_at

6048

8118535

8150356

8178188

8179472

A_23_P320200

A_23_P8095

A_32_P185149

GE62145

GO:0003824

GO:0004842

GO:0005515

GO:0005739

GO:0005783

GO:0005789

GO:0005886

GO:0006511

GO:0006914

GO:0008270

GO:0009617

GO:0010507

GO:0016020

GO:0016567

GO:0016740

GO:0030163

GO:0031648

GO:0031966

GO:0036211

GO:0036503

GO:0042802

GO:0043226

GO:0044390

GO:0044877

GO:0046872

GO:0055085

GO:0061630

GO:0070534

GO:0070936

GO:0071712

GO:0140096

GO:2000785

HMNXSV003008559

HMNXSV003047858

ILMN_2044927

PH_hs_0030665

PH_hs_0039561

TC06000395.hg

TC06002724.hg

TC08002294.hg

TC6_apd_hap1000044.hg

TC6_cox_hap2000087.hg

TC6_mann_hap4000071.hg

TC6_mcf_hap5000073.hg

TC6_qbl_hap6000078.hg

TC6_ssto_hap7000073.hg

U89336_cds4_at

g13278761_3p_at

Participates

as a member of

Inferred To

RNF5 [endoplasmic reticulum membrane] (Bos taurus)

RNF5 [endoplasmic reticulum membrane] (Canis familiaris)

RNF5 [endoplasmic reticulum membrane] (Sus scrofa)

Rnf5 [endoplasmic reticulum membrane] (Mus musculus)

Rnf5 [endoplasmic reticulum membrane] (Rattus norvegicus)

rnf-5 [endoplasmic reticulum membrane] (Caenorhabditis elegans)

sordd2 [endoplasmic reticulum membrane] (Drosophila melanogaster)

sordd1 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Dmel\CG32847 [endoplasmic reticulum membrane] (Drosophila melanogaster)

BcDNA:AT26376 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Homologues of RNF5 [endoplasmic reticulum membrane] (Drosophila melanogaster)

Dmel\CG34308 [endoplasmic reticulum membrane] (Drosophila melanogaster)

rnf5 [endoplasmic reticulum membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_008844.1

OpenTargets

ENSG00000204308

GeneCards

Q99942

HPA

ENSG00000204308-RNF5

Ensembl

ENSG00000227277, ENSG00000223767, ENSP00000415784, ENSP00000387879, ENSP00000415127, ENST00000413786, ENSG00000204308, ENST00000456167, ENSP00000413131, ENSG00000228907, ENSG00000183574, ENST00000375094, ENSP00000364235, ENSP00000388795, ENST00000445885, ENSP00000401172, ENSG00000228405, ENST00000453473, ENST00000432616, ENST00000449794, ENSG00000225452

PRO

Q99942

Pharos - Targets

Q99942

HMDB Protein

HMDBP09302

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P61077 UBE2D3	3	UBE2D3 [nucleoplasm] (R-HSA-205341) UBE2D3 [cytosol] (R-HSA-934630) Ub-C85-UBE2D3 [cytosol] (R-HSA-8864191)	0.841	11
UniProt:P51668 UBE2D1	3	UBE2D1 [cytosol] (R-HSA-174236) UBE2D1 [nucleoplasm] (R-HSA-174197) Ub-C85-UBE2D1 [cytosol] (R-HSA-8864160)	0.795	10
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.718	8
UniProt:P49023 PXN	4	p-Y-PXN [plasma membrane] (R-HSA-9031680) PXN [plasma membrane] (R-HSA-180493) PXN [cytosol] (R-HSA-210014) p-Y31,Y118-PXN [cytosol] (R-HSA-5218693)	0.591	6
UniProt:Q15758 SLC1A5	1	SLC1A5 [plasma membrane] (R-HSA-352376)	0.576	4
UniProt:Q96QD8 SLC38A2	1	SLC38A2 [plasma membrane] (R-HSA-352093)	0.576	3
UniProt:Q96CV9 OPTN	6	OPTN [recycling endosome membrane] (R-HSA-8854141) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [Golgi membrane] (R-HSA-2161111) OPTN [cytosol] (R-HSA-9687907) p-S177,S473,S513-OPTN [cytosol] (R-HSA-9687840)	0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3
UniProt:Q5VVQ6 YOD1	1	YOD1 [cytosol] (R-HSA-6781909)	0.556	3
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3

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